一种用于癌细胞检测、体外和体内成像的新型靶向成纤维细胞活化蛋白的近红外荧光开-关探针。
A novel fibroblast activation protein-targeted near-infrared fluorescent off-on probe for cancer cell detection, in vitro and in vivo imaging.
作者信息
Xing Jie, Gong Qiuyu, Zou Ruifen, Li Zihou, Xia Yuanzhi, Yu Zhangsen, Ye Yufan, Xiang Lingchao, Wu Aiguo
机构信息
Key Laboratory of Magnetic Materials and Devices, CAS & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, No. 1219 ZhongGuan West Road, 315201, Ningbo, China.
出版信息
J Mater Chem B. 2018 Mar 14;6(10):1449-1451. doi: 10.1039/c7tb03303f. Epub 2018 Feb 9.
A new hemicyanine-based fibroblast activation protein-targeted near-infrared fluorescent probe is designed and it shows high selectivity and sensitivity to cancer cell detection, and in vitro and in vivo imaging. This probe is successfully applied in fluorescence detection of living cells (with a detection limit of 1500 cells per mL). It is believed that many new functions or distributions of FAP could be discovered by this new probe later.
设计了一种基于新型半菁的成纤维细胞活化蛋白靶向近红外荧光探针，该探针在癌细胞检测以及体外和体内成像方面表现出高选择性和高灵敏度。该探针已成功应用于活细胞的荧光检测（检测限为每毫升1500个细胞）。相信该新型探针日后能够发现成纤维细胞活化蛋白的许多新功能或分布情况。
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