Nandwana Vikas, Singh Abhalaxmi, You Marisa M, Zhang Gefei, Higham John, Zheng Tiffany S, Li Yue, Prasad Pottumarthi V, Dravid Vinayak P
Department of Materials Science & Engineering, Northwestern University, Evanston, Illinois 60208, USA.
J Mater Chem B. 2018 Feb 21;6(7):1026-1034. doi: 10.1039/c7tb03160b. Epub 2018 Jan 17.
We report magnetic nanostructure-stabilized lipid nanocapsules (MLNCs) that show superior structural stability and theranostic properties compared to conventional lipid-based nanocarriers. As therapeutic nanocarriers, the MLNCs exhibit a therapeutic efficacy that is 16 times greater than that of free drugs due to their high payload capacity and actuated drug release ability. In addition, the magnetic resonance contrast enhancement of the MLNCs is nine times higher than that of a clinically approved T MRI contrast agent (ferumoxytol), demonstrating the diagnostic imaging capability of the MLNCs in MRI. The self-assembly method to synthesize the lipid nanocapsules is extended to other types of nanoparticles (gold nanoparticles and quantum dots) to produce lipid nanohybrids with distinct physical properties.
我们报道了磁性纳米结构稳定的脂质纳米胶囊（MLNCs），与传统的脂质基纳米载体相比，其具有卓越的结构稳定性和诊疗性能。作为治疗性纳米载体，MLNCs展现出的治疗效果比游离药物高16倍，这归因于其高载药量和触发式药物释放能力。此外，MLNCs的磁共振造影增强效果比临床批准的T MRI造影剂（ ferumoxytol）高9倍，证明了MLNCs在MRI中的诊断成像能力。合成脂质纳米胶囊的自组装方法被扩展到其他类型的纳米颗粒（金纳米颗粒和量子点），以制备具有独特物理性质的脂质纳米杂化物。
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