Nandwana Vikas, Ryoo Soo-Ryoon, Zheng Tiffany, You Marisa M, Dravid Vinayak P
ACS Biomater Sci Eng. 2019 Jun 10;5(6):3049-3059. doi: 10.1021/acsbiomaterials.9b00361. Epub 2019 May 14.
Here we report design of a smart nanoconstruct that can be used as a multimodal theranostic platform for imaging and therapy applications. Decorated with two sizes of magnetic nanostructures (MNS) on thermoresponsive nanosized hydrogel (NG), the NG-MNS nanoconstruct shows dual-mode contrast enhancement ability in MRI and thermo-chemo therapeutic ability under an RF field. Because of the unique design where all MNS are at the exterior of the nanoconstruct, no compromise in the physical properties of MNS and their effect on contrast enhancement and thermal activation has been observed. In a series of in vitro analyses in human breast adenocarcinoma (MDA-MB-231) cells, we validate that NG-MNS show dual-mode MR imaging capability with a higher signal/noise ratio than in clinically approved dual-mode contrast agents as well as enhanced therapeutic efficacy compared to previously reported hydrogel-based nanocarriers and free drug systems.
在此，我们报告了一种智能纳米结构的设计，该结构可作为用于成像和治疗应用的多模态诊疗平台。在热响应性纳米水凝胶（NG）上装饰有两种尺寸的磁性纳米结构（MNS），NG-MNS纳米结构在MRI中显示出双模式对比度增强能力，并在射频场下具有热化疗治疗能力。由于所有MNS都位于纳米结构外部的独特设计，未观察到MNS的物理性质受到影响及其对对比度增强和热激活的作用。在一系列针对人乳腺腺癌（MDA-MB-231）细胞的体外分析中，我们验证了NG-MNS具有双模式磁共振成像能力，其信噪比高于临床批准的双模式造影剂，并且与先前报道的基于水凝胶的纳米载体和游离药物系统相比，具有更高的治疗效果。
