Cheng Huan, Li Chaojing, Jiang Yujia, Wang Bijia, Wang Fujun, Mao Zhiping, Xu Hong, Wang Lu, Sui Xiaofeng
Key Lab of Science and Technology of Eco-textile, Ministry of Education, Donghua University, China.
J Mater Chem B. 2018 Jan 28;6(4):634-640. doi: 10.1039/c7tb03000b. Epub 2018 Jan 10.
Wound exudate adsorption and blood clotting are of critical importance for promoting wound healing in diabetic patients. In this study, cellulose-chitosan hybrid sponges were prepared by a facile pathway with controllable structure and morphology. Aimed at wound dressing, the physical properties, cytocompatibility, and hemocompatibility of the cellulose-chitosan hybrid sponges were evaluated. The results indicated that the hybrid sponges were non-toxic and outperformed silicon in promoting blood coagulation. The sponges could also effectively adsorb abundant wound exudate due to their highly porous structure. Moreover, the maximal shape recovery of these chemically crosslinked sponges from a 50% compression strain was up to 95% of their original thickness, without obviously compromising their macro/microstructure and mechanical properties after 10 cycles. The superior blood coagulation, adsorption performance, and shape recovery properties of the sponges make them ideal for use in making wound dressings for diabetic patients.
伤口渗出液吸附和血液凝固对于促进糖尿病患者伤口愈合至关重要。在本研究中，通过简便途径制备了具有可控结构和形态的纤维素-壳聚糖混合海绵。针对伤口敷料，评估了纤维素-壳聚糖混合海绵的物理性质、细胞相容性和血液相容性。结果表明，混合海绵无毒，在促进血液凝固方面优于硅。由于其高度多孔的结构，这些海绵还能有效吸附大量伤口渗出液。此外，这些化学交联海绵从50%压缩应变下的最大形状恢复率高达其原始厚度的95%，在10个循环后其宏观/微观结构和机械性能没有明显受损。海绵优异的凝血、吸附性能和形状恢复性能使其成为制备糖尿病患者伤口敷料的理想材料。
