Shi Lei, Li Kun, Cui Peng-Cheng, Li Ling-Ling, Pan Sheng-Lin, Li Meng-Yang, Yu Xiao-Qi
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China.
J Mater Chem B. 2018 Jul 21;6(27):4413-4416. doi: 10.1039/c8tb00774h. Epub 2018 May 31.
As fluorescent probes, the small Stokes shift and ACQ effect limit the application of BINOL derivatives. Herein, a new series of BINOL derivatives were synthesized which could be turned from ACQ to AIE fluorophores by changing the electron withdrawing group. Among these compounds, BIN-COP exhibits an obvious AIE property with low cytotoxicity. The bioimaging performance indicated that the designed fluorophores could be successfully used for bioimaging.
作为荧光探针，较小的斯托克斯位移和聚集诱导猝灭（ACQ）效应限制了联萘酚（BINOL）衍生物的应用。在此，合成了一系列新的BINOL衍生物，通过改变吸电子基团，它们可以从ACQ荧光团转变为聚集诱导发光（AIE）荧光团。在这些化合物中，BIN-COP表现出明显的AIE性质且细胞毒性较低。生物成像性能表明，所设计的荧光团可成功用于生物成像。
