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Lysosome-targeting ratiometric fluorescent pH probes based on long-wavelength BODIPY.

作者信息

Zhu Mengliang, Xing Peipei, Zhou Yabin, Gong Lei, Zhang Jinghui, Qi Dongdong, Bian Yongzhong, Du Hongwu, Jiang Jianzhuang

机构信息

Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, Department of Chemistry, University of Science and Technology Beijing, Beijing 100083, China.

出版信息

J Mater Chem B. 2018 Jul 21;6(27):4422-4426. doi: 10.1039/c8tb00883c. Epub 2018 Jun 28.

DOI:10.1039/c8tb00883c
PMID:32254659
Abstract

BODIPY-based probes were developed for the ratiometric fluorescence detection of pH values. They showed high sensitivity under acidic conditions via a protonation-modulated ICT mechanism and could selectively stain lysosomes, and thus could be applied for imaging and detecting abnormal pH decreases in live cells.

摘要

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