Li Bing-Nan, He Ping-Ping, Yang Pei-Pei, Zhang Jing-Ping, Wang Lei, Wang Hao
Faculty of Chemistry, Northeast Normal University, Changchun, China.
J Mater Chem B. 2018 Aug 28;6(32):5282-5289. doi: 10.1039/c8tb00974k. Epub 2018 Aug 1.
Tumor metastasis as the most common reason of death from cancer has always been a great challenge in both clinical and scientific research, where angiogenesis plays a necessary role. Herein, we report an extracellularly transformable nanomaterial for in situ construction of defensive networks on interaction with vascular endothelial growth factor (VEGF) for anti-angiogenic therapy of tumor. The fibrous networks exhibit transformation-enhanced accumulation and retention (TEAR) effects (over 72 h), and bind and intercept cell-secreted VEGF over particulate and molecular anti-angiogenic agents with high efficiency, leading to anti-angiogenesis. This study demonstrates that angiogenesis is positively related to tumor growth as well as tumor metastasis; the anti-angiogenic therapy inhibits tumor metastasis with an inhibition rate of 65.9%. In addition, this extracellular strategy of transformation may be utilized to bind huge amounts of cell-secreted biomolecules/factors or receptors on cell surfaces and inhibit their functionalities for cancer therapy.
肿瘤转移作为癌症最常见的死亡原因，一直是临床和科研中的巨大挑战，而血管生成在其中起着必要作用。在此，我们报道了一种可在细胞外转化的纳米材料，它在与血管内皮生长因子（VEGF）相互作用时可原位构建防御网络，用于肿瘤的抗血管生成治疗。纤维网络表现出转化增强的积累和滞留（TEAR）效应（超过72小时），并能高效结合和拦截细胞分泌的VEGF，优于颗粒状和分子抗血管生成剂，从而导致抗血管生成。本研究表明，血管生成与肿瘤生长以及肿瘤转移呈正相关；抗血管生成治疗可抑制肿瘤转移，抑制率为65.9%。此外，这种细胞外转化策略可用于结合大量细胞分泌的生物分子/因子或细胞表面受体，并抑制它们在癌症治疗中的功能。
