Matsuda Y, Ikenoue T, Kamitomo M, Matsumoto T, Hokanishi H
Perinatal Medical Center, Kagoshima Municipal Hospital.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 Oct;40(10):1531-4.
The effects of amniocentesis on the prolongation of the gestational period was retrospectively reviewed in patients, in premature labor with intact membranes between 24 and 36 weeks of gestation. Amniocentesis was performed on 55 patients (study group) to evaluate fetal lung maturity and to detect subclinical intraamniotic infection, while the remaining 170 patients (control group) did not receive this procedure. Isoxsuprine was used as the primary tocolytic agent in all the patients. There was no difference in the incidence of spontaneous rupture of the membranes during tocolysis (3/55 vs. 7/170), cesarean deliveries (3/55 vs. 10/170), and adjunctive use of magnesium sulfate with isoxsuprine (11/55 vs. 31/170). A statistical analysis of the time interval from amniocentesis to vaginal delivery at each score of the tocolysis index failed to show any evidence that amniocentesis might induce labor. Moreover, no maternal or neonatal morbidity was attributable to amniocentesis. These data suggest that the use of amniocentesis may be a helpful procedure in the management of premature labor with intact membranes with minimum effect on the outcome of the clinical course.
对妊娠24至36周胎膜完整的早产患者进行回顾性研究，分析羊膜腔穿刺术对妊娠期延长的影响。对55例患者（研究组）进行羊膜腔穿刺术，以评估胎儿肺成熟度并检测亚临床羊膜腔内感染，其余170例患者（对照组）未接受该操作。所有患者均使用异克舒令作为主要的宫缩抑制剂。在宫缩抑制期间，两组患者的胎膜自然破裂发生率（3/55 vs. 7/170）、剖宫产率（3/55 vs. 10/170）以及异克舒令联合硫酸镁的使用率（11/55 vs. 31/170）均无差异。对宫缩抑制指数各评分下从羊膜腔穿刺术到阴道分娩的时间间隔进行统计分析，未发现任何证据表明羊膜腔穿刺术可能诱发分娩。此外，没有产妇或新生儿的发病可归因于羊膜腔穿刺术。这些数据表明，在胎膜完整的早产管理中，使用羊膜腔穿刺术可能是一种有用的操作，对临床病程结局的影响最小。
