Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650091, P. R. China.
J Mater Chem B. 2019 Mar 7;7(9):1469-1474. doi: 10.1039/c8tb02870b. Epub 2019 Feb 11.
Covalent organic frameworks (COFs) are a class of crystalline porous materials utilized in various potential applications. However, the development of hollow-structured COFs with defined morphology is important for their further applications, which is rare. Herein, COF with unique hollow shuttle morphology was prepared by a Schiff condensation reaction between 4-(4-aldehyde phenyl)ethylene (TPE) and tetra-(4-aminophenyl) porphyrin (TAP). A detailed mechanistic investigation reveals that an initial self-assembly followed by a similar inside-out Ostwald ripening process is responsible for the hollow capsule formation. The hollow microshuttle-shaped capsule COF is used for studying hemoglobin adsorption, which shows an uptake of 550.82 mg g of hemoglobin. These studies could foreshadow new avenues for the development of porous materials with defined morphologies for the adsorption of biomolecules.
共价有机框架（COFs）是一类用于各种潜在应用的结晶多孔材料。然而，开发具有明确定义形态的中空结构 COFs 对于它们的进一步应用非常重要，但这种 COFs 却很少见。在此，通过 4-（4-醛基苯基）乙烯（TPE）和四-（4-氨基苯基）卟啉（TAP）之间的席夫缩合反应制备了具有独特中空梭形形态的 COF。详细的机理研究表明，初始自组装随后是类似的内外 Ostwald 熟化过程负责中空胶囊的形成。中空微梭形胶囊 COF 用于研究血红蛋白吸附，其血红蛋白吸附量为 550.82mg g。这些研究为开发用于生物分子吸附的具有明确定义形态的多孔材料开辟了新途径。
