Toro-González M, Copping R, Mirzadeh S, Rojas J V
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA.
J Mater Chem B. 2018 Dec 21;6(47):7985-7997. doi: 10.1039/c8tb02173b. Epub 2018 Nov 20.
Gadolinium vanadate nanoparticles (NPs) doped with europium, in concentrations between 5-40%, were synthesized via an aqueous route to prove their multimodal imaging functionalities and their performance as radionuclide carriers for targeted alpha therapy. Core-shell GdEuVO NPs were doped with the α-emitting actinium-225 to assess the in vitro retention of Ac and its decay daughters; francium-221 and bismuth-213. GdEuVO core-shell NPs were obtained using a precipitation synthesis route having a tetragonal system, a spherical morphology, and a uniform particle size distribution. GdEuVO core-shell NPs displayed the characteristic intense emission at 618 nm (red) and paramagnetic behavior of Eu and Gd cations, respectively. Partial retention of radionuclides was obtained with GdEuVO core NPs, while deposition of two nonradioactive GdEuVO shells significantly decreased the leakage of both Ac and Fr. The luminescence and magnetic functionalities as well as radionuclide retention capabilities of GdEuVO core-shell NPs demonstrate their potential for biomedical applications.
通过水相法合成了铕掺杂浓度为5%-40%的钒酸钆纳米颗粒（NPs），以证明其多模态成像功能以及作为靶向α治疗的放射性核素载体的性能。核壳结构的GdEuVO NPs被掺杂了发射α粒子的锕-225，以评估锕及其衰变子体（钫-221和铋-213）的体外保留情况。采用沉淀合成路线获得了具有四方晶系、球形形态和均匀粒径分布的GdEuVO核壳纳米颗粒。GdEuVO核壳纳米颗粒分别在618 nm（红色）处显示出特征性的强发射以及铕和钆阳离子的顺磁行为。GdEuVO核纳米颗粒实现了放射性核素的部分保留，而沉积两层非放射性的GdEuVO壳层显著降低了锕和钫的泄漏。GdEuVO核壳纳米颗粒的发光和磁性功能以及放射性核素保留能力证明了它们在生物医学应用中的潜力。
