高响应性和快速过氧化氢触发的聚己内酯纳米粒子降解。
Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles.
机构信息
Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Department of NanoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
出版信息
Biomater Sci. 2020 May 6;8(9):2394-2397. doi: 10.1039/c9bm02019e.
PMID:32255451
Abstract
We synthesized an oxidation-responsive polycaprolactone (O-PCL) bearing pendant arylboronic esters as H2O2-responsive motifs. H2O2 induces fast depolymerization of O-PCL within days. Nanoparticles formulated from O-PCL disintegrate and release payload in response to concentrations of H2O2 (50 μM) that are relevant to human disease.
摘要
我们合成了一种氧化响应性聚己内酯（O-PCL），其带有芳基硼酸酯作为 H2O2 响应性结构单元。H2O2 诱导 O-PCL 在数天内快速解聚。由 O-PCL 制成的纳米粒子在与人类疾病相关的 H2O2 浓度（50 μM）下会崩解并释放有效载荷。
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