Department of Clinical Sciences (Huvé, O'Toole, Fontaine, Bélanger) and Department of Pathology and Microbiology (Gara-Boivin), Faculty of Veterinary Medicine, University of Montreal, C.P. 5000, Saint-Hyacinthe, Quebec J2S 7C6.
Can J Vet Res. 2020 Apr;84(2):138-145.
Although hepatobiliary disease is common in cats, little is known about the bile composition in either these diseased states or in healthy cats. The objectives of this study were to evaluate several analytes from the bile of healthy cats and to investigate the usefulness of measuring these variables to predict bacterial cholangitis. Cats were prospectively enrolled and divided into 3 groups: 21 healthy cats (group 1) and 14 cats with suspected hepatobiliary disease: 9 without bacterial biliary infection (group 2) and 5 with bacterial biliary infection (group 3). Percutaneous ultrasound-guided cholecystocentesis was conducted on each cat. Bile cytology and culture were carried out and bile was analyzed for pH, lactate, and glucose levels using several point-of-care (POC) devices. Reference values for several bile analytes in healthy cats were calculated and are presented in this study. Neither the pH ( = 0.88) nor the lactate concentration ( = 0.85) was significantly different among the 3 groups. Sodium concentration was significantly higher in group 3 than in group 2 ( < 0.05). Bile pH, lactate, and glucose levels were unable to predict the presence of a bacterial infection in the bile.
尽管肝胆疾病在猫中很常见，但对于这些疾病状态或健康猫的胆汁成分知之甚少。本研究的目的是评估健康猫胆汁中的几种分析物，并研究测量这些变量预测细菌性胆管炎的有用性。前瞻性纳入了 21 只健康猫（第 1 组）和 14 只疑似肝胆疾病的猫：9 只无细菌胆道感染（第 2 组）和 5 只细菌胆道感染（第 3 组）。对每只猫进行经皮超声引导下胆囊穿刺术。进行胆汁细胞学和培养，并使用几种即时检测（POC）设备分析胆汁的 pH 值、乳酸和葡萄糖水平。本研究计算并提供了健康猫几种胆汁分析物的参考值。3 组间 pH 值（=0.88）和乳酸浓度（=0.85）均无显著差异。第 3 组的钠浓度显著高于第 2 组（<0.05）。胆汁 pH 值、乳酸和葡萄糖水平均无法预测胆汁中是否存在细菌感染。
