Akdoğan E, Ayaz T, Kırbaş A, Rakıcı H
Department of Hematology, Recep Tayyip Erdogan University Medical Faculty, Research and Training Hospital, Rize, Turkey.
Department of Internal Medicine, Recep Tayyip Erdogan University Medical Faculty, Research and Training Hospital, Rize, Turkey.
Hippokratia. 2019 Jan-Mar;23(1):21-24.
Signal peptide-CUB-EGF-like domain-containing protein 1 (SCUBE1) is expressed in vascular endothelium and human platelets. SCUBE1 levels are increased in acute arterial thrombosis. Multiple myeloma patients are also at increased risk of arterial thrombotic events. This study aimed to measure SCUBE1 levels in newly diagnosed multiple myeloma patients and to define whether SCUBE1 could be a useful marker determining the arterial thrombotic risk.
SCUBE1 levels of 32 newly diagnosed multiple myeloma patients and 41 healthy control subjects were measured by enzyme-linked immunosorbent assay.
Plasma SCUBE1 levels of multiple myeloma patients and control subjects were 6.22 ± 0.9 and 7.95 ± 1.1 ng/ml, respectively. In the patient group, SCUBE1 levels were significantly lower compared to control subjects (p <0.001).
SCUBE1 level measuring does not help to predict the arterial thrombotic risk in multiple myeloma patients. The significantly lower levels of SCUBE1 in multiple myeloma patients are likely to be due to defective platelets and/or increased TNF-α cytokines and is another proof of platelet dysfunction seen in these patients. HIPPOKRATIA 2019, 23(1): 21-24.
含信号肽-CUB-表皮生长因子样结构域蛋白1（SCUBE1）在血管内皮和人血小板中表达。急性动脉血栓形成时SCUBE1水平升高。多发性骨髓瘤患者发生动脉血栓事件的风险也增加。本研究旨在测定新诊断的多发性骨髓瘤患者的SCUBE1水平，并确定SCUBE1是否可作为判断动脉血栓形成风险的有用标志物。
采用酶联免疫吸附测定法测量32例新诊断的多发性骨髓瘤患者和41例健康对照者的SCUBE1水平。
多发性骨髓瘤患者和对照者的血浆SCUBE1水平分别为6.22±0.9和7.95±1.1 ng/ml。在患者组中，SCUBE1水平显著低于对照者（p<0.001）。
测量SCUBE1水平无助于预测多发性骨髓瘤患者的动脉血栓形成风险。多发性骨髓瘤患者SCUBE1水平显著降低可能是由于血小板缺陷和/或肿瘤坏死因子-α细胞因子增加，这也是这些患者血小板功能障碍的另一个证据。《希波克拉底》2019年，23(1): 21 - 24。
