SCUBE1 是否是胃癌的一个新生物标志物？
Is SCUBE 1 a new biomarker for gastric cancer?
机构信息
Medical Laboratory Program, Karadeniz Technical University, Vocational School of Health Sciences, Trabzon, Turkey.
出版信息
Cancer Biomark. 2012;11(5):191-5. doi: 10.3233/CBM-2012-00285.
PURPOSES
This study was intended to determine the diagnostic significance of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE 1) levels in gastric cancer.
METHODS
This retrospective study was conducted with patients with gastric cancer. SCUBE 1 titers of plasma in patients with gastric cancer were determined using an enzyme-linked immunosorbent assay (ELISA).
RESULTS
SCUBE 1 titers of gastric cancer patients were significantly higher compared with the control group (P=0.0001). At a SCUBE 1 cut-off point of 43 ng/mL, sensitivity was 67%, specificity 91%, positive predictive values (PPV) 92% and negative predictive values(NPV) 63%. SCUBE 1 levels of patients with methastase were not different from patients without methastase (P> 0.05). DICUSSIONS: SCUBE 1 levels in patients with gastric cancer were found higher compared to healthy subjects.
目的
本研究旨在确定信号肽-CUB-EGF 结构域包含蛋白 1（SCUBE1）水平在胃癌中的诊断意义。
方法
本回顾性研究纳入了胃癌患者。采用酶联免疫吸附试验（ELISA）测定胃癌患者血浆中 SCUBE1 的浓度。
结果
与对照组相比，胃癌患者的 SCUBE1 浓度明显升高（P=0.0001）。在 SCUBE1 截断值为 43ng/mL 时，敏感性为 67%，特异性为 91%，阳性预测值（PPV）为 92%，阴性预测值（NPV）为 63%。有转移的患者和没有转移的患者的 SCUBE1 水平没有差异（P>0.05）。
讨论
与健康受试者相比，胃癌患者的 SCUBE1 水平升高。
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