Morotti Alessandro, Branca Enrica, Guerrasio Angelo
Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
J Blood Med. 2020 Mar 19;11:103-105. doi: 10.2147/JBM.S232109. eCollection 2020.
The reversal of low-molecular-weight heparin (LMWH) and the management of bleeding patients on LMWH remain highly challenging. Even if LMWH is very extensively administered in the prophylaxis and treatment of venous thrombosis, specific antidotes are lacking, and reversal strategies have very weak grade of evidences on clinical effectiveness. We here describe a reversal strategy with protamine and FVIIa in a patient presenting with hemorrhagic shock and cardiocirculatory arrest.
低分子量肝素（LMWH）的逆转以及接受LMWH治疗的出血患者的管理仍然极具挑战性。即使LMWH在静脉血栓形成的预防和治疗中得到广泛应用，但仍缺乏特效解毒剂，且逆转策略在临床有效性方面的证据等级非常低。我们在此描述了一例使用鱼精蛋白和FVIIa对出现失血性休克和心循环骤停的患者进行逆转的策略。
