Laidi Charles, Levenes Carole, Suarez-Perez Alex, Février Caroline, Durand Florence, Bouaziz Noomane, Januel Dominique
Pôle de Psychiatrie, Assistance Publique-Hôpitaux de Paris (AP-HP), Faculté de Médecine de Créteil, DMU IMPACT, Hôpitaux Universitaires Mondor, Créteil, France.
Institut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle, Créteil, France.
Front Psychiatry. 2020 Mar 17;11:174. doi: 10.3389/fpsyt.2020.00174. eCollection 2020.
Cerebellum plays a role in the regulation of cognitive processes. Cerebellar alterations could explain cognitive impairments in schizophrenia. We describe the case of a 50 years old patient with schizophrenia whom underwent cerebellar transcranial direct current stimulation (tDCS). In order to study the effect of cerebellar stimulation on cognitive functions, the patient underwent a neuropsychological assessment and an eyeblink conditioning (EBC) protocol. Although the effect of brain stimulation cannot be only assessed in a single-case study, our results suggest that cerebellar stimulation may have an effect on a broad range of cognitive functions typically impaired in patients with schizophrenia, including verbal episodic, short term, and working memory. In addition to neuropsychological tests, we evaluated the cerebellar function by performing EBC before and after tDCS. Our data suggest that tDCS can improve EBC. Further clinical trials are required for better understanding of how cerebellar stimulation can modulate cognitive processes in patients with schizophrenia and healthy controls.
小脑在认知过程的调节中发挥作用。小脑改变可能解释精神分裂症的认知障碍。我们描述了一例50岁精神分裂症患者接受小脑经颅直流电刺激（tDCS）的病例。为了研究小脑刺激对认知功能的影响，该患者接受了神经心理学评估和眨眼条件反射（EBC）方案。尽管脑刺激的效果不能仅在单病例研究中评估，但我们的结果表明，小脑刺激可能对精神分裂症患者通常受损的广泛认知功能产生影响，包括言语情景记忆、短期记忆和工作记忆。除了神经心理学测试外，我们在tDCS前后通过进行EBC来评估小脑功能。我们的数据表明tDCS可以改善EBC。需要进一步的临床试验来更好地了解小脑刺激如何调节精神分裂症患者和健康对照者的认知过程。
