He Xidong, Gao Yuanxue, Liu Qi, Zhao Zhifang, Deng Wanhang, Yang Hong
Department of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Department of Gastroenterology, Guizhou Provincial People's Hospital, Guiyang 550002, China.
Gastroenterol Res Pract. 2020 Mar 20;2020:2056168. doi: 10.1155/2020/2056168. eCollection 2020.
To investigate the diagnostic value of interferon-gamma release assays combined with multiple indicators for tuberculous peritonitis.
Patients who were admitted to the hospital due to suspected tuberculous peritonitis were prospectively included during the 30-month study period. Moreover, healthy individuals were recruited and included in the control group. All the study participants were assessed using various indexes, such as interferon-gamma release assays.
A total of 180 patients with suspected tuberculous peritonitis were enrolled, and 24 were excluded. 73 patients with a confirmed diagnosis of tuberculous peritonitis were included in the tuberculous peritonitis group, 83 patients with other diseases in the other-disease control group, and 52 healthy individuals in the control group. Moreover, 83 patients in the other-disease control group and 52 participants in the control group were identified as 135 nontuberculous peritonitis patients. The area under the receiver operating characteristics curve for the QuantiFERON-TB test was 0.851 (95% confidence interval: 0.799-0.903), and the optimal cutoff value was 0.55 IU/mL, which corresponds to a sensitivity and specificity of 86.30% and 80.00%, respectively. The receiver operating characteristic curves for the combination of the QuantiFERON-TB test and the use of erythrocyte sedimentation rate, serum adenosine deaminase level, serum cancer antigen 125 level, and hypersensitive C-reactive protein level had an area under the curve of 0.859 (95% confidence interval: 0.809-0.909), with a sensitivity and specificity of 97.26% and 62.96%, respectively.
The combined use of the QuantiFERON-TB test and multiple indexes can significantly improve the accuracy of diagnosing tuberculous peritonitis.
探讨γ-干扰素释放试验联合多项指标对结核性腹膜炎的诊断价值。
在30个月的研究期间，前瞻性纳入因疑似结核性腹膜炎入院的患者。此外，招募健康个体并纳入对照组。所有研究参与者均使用多种指标进行评估，如γ-干扰素释放试验。
共纳入180例疑似结核性腹膜炎患者，排除24例。结核性腹膜炎组纳入确诊为结核性腹膜炎的患者73例，其他疾病对照组纳入83例其他疾病患者，对照组纳入52例健康个体。此外，其他疾病对照组的83例患者和对照组的52例参与者被确定为135例非结核性腹膜炎患者。QuantiFERON-TB检测的受试者工作特征曲线下面积为0.851（95%置信区间：0.799 - 0.903），最佳截断值为0.55 IU/mL，对应的灵敏度和特异度分别为86.30%和80.00%。QuantiFERON-TB检测与红细胞沉降率、血清腺苷脱氨酶水平、血清癌抗原125水平和超敏C反应蛋白水平联合使用的受试者工作特征曲线下面积为0.859（95%置信区间：0.809 - 0.909），灵敏度和特异度分别为97.26%和62.96%。
QuantiFERON-TB检测与多项指标联合使用可显著提高结核性腹膜炎的诊断准确性。
