Biochemical Characteristics of Bone Mineral Metabolism before and throughout the First Year after Kidney Transplantation, Persistent Hyperparathyroidism, and Risk Factors in a Latin Population.

Bone mineral metabolism disease, which included persistent hyperparathyroidism, is common after successful kidney transplantation (KT) and is related with negative outcomes in kidney transplant recipients. There is a lack of information about bone mineral metabolism, persistent hyperparathyroidism, and its risk factors in Latin kidney transplant recipients (KTRs). : A retrospective study was conducted in 74 patients aged 18-50 years with evolution of 12 months after KT and estimated glomerular filtration rate (eGFR) >60 ml/min; biochemical data of bone mineral metabolism before and at 1, 3, 6, and 12 months of KT were registered. Age was 33 (IQR 27-37) years; 54% ( = 40) were men. Before KT, all patients had hyperparathyroidism, 40% ( = 30) hypocalcemia, 86% ( = 64) hyperphosphatemia, and 42% ( = 31) hyperphosphatasemia. After KT, an increase of calcium and a diminution of PTH, phosphorus, and alkaline phosphatase were corroborated (=0.001). All patients had hypovitaminosis D (deficiency: 91% ( = 67); insufficiency: 9% ( = 7)); 40% ( = 30) had persistent hyperparathyroidism at 12 months. Hyperphosphatasemia before KT (OR = 4.17 (95% CI: 1.21-14.44); =0.04), hyperparathyroidism at 6 months (OR = 1.84 (95% CI; 1.67-2.06); =0.02), hypovitaminosis D at 6 months (OR = 3.94 (95% CI: 1.86-17.9); =0.01), and hyperphosphatasemia at 6 months (OR = 1.47 (95% CI: 1.07-2.86); =0.03) were risk factors for persistent hyperparathyroidism at 12 months after KT. . Persistent hyperparathyroidism at 6 months, hypovitaminosis D, and hyperphosphatasemia are risk factors for persistent hyperparathyroidism at 1 year of KT in Latin population.