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吸烟与非吸烟女性味觉阈值敏感性与基质金属蛋白酶-9、唾液分泌、血压及血糖水平之间的相关性

Correlation between Taste Threshold Sensitivity and MMP-9, Salivary Secretion, Blood Pressure, and Blood Glucose Levels in Smoking and Nonsmoking Women.

作者信息

Tjahajawati Sri, Rafisa Anggun, Murniati Nani, Zubaedah Cucu

机构信息

Department of Oral Biology, University of Padjadjaran, Bandung 40132, Indonesia.

Department of Dental Health Community, University of Padjadjaran, Bandung 40132, Indonesia.

出版信息

Int J Dent. 2020 Mar 12;2020:4178674. doi: 10.1155/2020/4178674. eCollection 2020.

Abstract

Cigarette smoking can cause taste receptors to increase the taste threshold value. Consequently, the consumption of sugar and salt will not be controlled, therefore causing systemic diseases such as hypertension and diabetes. Nicotine and tobacco in cigarettes can stimulate MMP-9 which plays vital physiological roles in normal tissue growth and repair processes. This study aimed to find the correlation between taste threshold sensitivity and MMP-9, salivary secretion, blood pressure, and blood glucose levels in smoking and nonsmoking women. This was a cross-sectional study consisting of young adult women aged 18-24 years. Subjects were divided into two groups: the nonsmoking and smoking groups. In the combined data of both groups, the sweet taste threshold was correlated with age ( = 0.308, =0.008), blood glucose levels ( = 0.238, =0.043), and MMP-9 ( = -0.297, =0.011). The salt taste threshold was only correlated with systolic blood pressure in the smoking ( = 0.440, =0.032) and combined data groups ( = 0.260, =0.026). By using partial correlation, it was shown that the relationship between the salt taste threshold and systolic blood pressure was influenced by smoking habits. The sweet taste threshold in women was found to correlate with age, blood glucose levels, and MMP-9 levels. On the other hand, there was a significant relationship between the salt taste threshold in women with systolic blood pressure, which was the only correlation analyzed in sthis study that was found to be influenced by smoking. However, both sweet and salt taste thresholds were not statistically correlated with salivary secretion.

摘要

吸烟会导致味觉感受器提高味觉阈值。因此,糖和盐的摄入量将无法得到控制,进而引发高血压和糖尿病等全身性疾病。香烟中的尼古丁和烟草会刺激基质金属蛋白酶-9(MMP-9),其在正常组织生长和修复过程中发挥着重要的生理作用。本研究旨在探究吸烟和不吸烟女性的味觉阈值敏感性与MMP-9、唾液分泌、血压和血糖水平之间的相关性。这是一项横断面研究,研究对象为18至24岁的年轻成年女性。受试者被分为两组:不吸烟组和吸烟组。在两组的合并数据中,甜味阈值与年龄(r = 0.308,P = 0.008)、血糖水平(r = 0.238,P = 0.043)和MMP-9(r = -0.297,P = 0.011)相关。咸味阈值仅与吸烟组(r = 0.440,P = 0.032)和合并数据组(r = 0.260,P = 0.026)的收缩压相关。通过偏相关分析表明,咸味阈值与收缩压之间的关系受吸烟习惯影响。研究发现,女性的甜味阈值与年龄、血糖水平和MMP-9水平相关。另一方面,女性的咸味阈值与收缩压之间存在显著关系,这是本研究中唯一一项发现受吸烟影响的相关性分析。然而,甜味和咸味阈值与唾液分泌均无统计学相关性。

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