Hosen Naoki
Department of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Suita, 1-7 Yamada-Oka, Suita, Osaka, 565-0871 Japan.
Inflamm Regen. 2020 Mar 30;40:4. doi: 10.1186/s41232-020-00113-y. eCollection 2020.
Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions in MM cells, and therefore are potential therapeutic targets. We have recently shown that integrin β7 constitutively adopts the active conformation specifically in MM cells, and found that chimeric antigen receptor (CAR) T cells targeting the activated conformation of integrin β7 is promising for MM. Although the mechanism for the constitutive activation is still being investigated, our results indicate that integrin conformation is different between MM and normal cells and suggest that it may be associated with the pathology of MM.
整合素在多发性骨髓瘤（MM）细胞的骨髓归巢、存活、增殖或耐药性方面发挥着关键作用。特别是，整合素α4β1（VLA-4）和α4β7已被报道在MM细胞中具有重要功能，因此是潜在的治疗靶点。我们最近发现，整合素β7在MM细胞中特异性地持续采用活性构象，并发现靶向整合素β7活性构象的嵌合抗原受体（CAR）T细胞对MM具有治疗潜力。尽管组成性激活的机制仍在研究中，但我们的结果表明，MM细胞与正常细胞的整合素构象不同，提示这可能与MM的病理机制有关。
