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直面显微镜下多血管炎(GPA):导致诊断延误的错失良机。

Look granulomatosis with polyangiitis (GPA) straight in the face: missed opportunities leading to a delayed diagnosis.

作者信息

Rolle N, Muruganandam M, Jan I, Harji F M, Harrington J, Konstantinov K N

机构信息

1Department of Medicine, Division of Rheumatology, University of New Mexico School of Medicine, Albuquerque, NM 87131 USA.

Section of Rheumatology, Raymond G. Murphy Veterans Affairs Medical Center, 1501 San Pedro SE, Albuquerque, NM 87108 USA.

出版信息

Auto Immun Highlights. 2019 Sep 17;10(1):8. doi: 10.1186/s13317-019-0118-4. eCollection 2019 Dec.

DOI:10.1186/s13317-019-0118-4
PMID:32257064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7065353/
Abstract

Granulomatosis with polyangiitis (GPA) is a systemic vasculitis with a potential to involve any organ system. It remains an important cause of kidney related morbidity and mortality. Early diagnosis can be difficult and requires high index of suspicion in all patients, but especially in cases with atypical presentation. We report a case with GPA, which was diagnosed only after new and advancing symptoms belied the original diagnosis of bilateral facial palsy and aortic mural thrombus.

摘要

肉芽肿性多血管炎(GPA)是一种可累及任何器官系统的系统性血管炎。它仍然是导致肾脏相关发病和死亡的重要原因。早期诊断可能困难,需要对所有患者,尤其是表现不典型的病例保持高度怀疑。我们报告一例GPA病例,该病例仅在新出现和进展性症状与最初诊断的双侧面神经麻痹和主动脉壁血栓不符后才得以确诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/7065353/b15f860c9a45/13317_2019_118_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/7065353/ca8410dd1d78/13317_2019_118_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/7065353/b15f860c9a45/13317_2019_118_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/7065353/ca8410dd1d78/13317_2019_118_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb6/7065353/b15f860c9a45/13317_2019_118_Fig2_HTML.jpg

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本文引用的文献

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Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study.肉芽肿伴多血管炎能否在初级保健中更早诊断?一项病例对照研究。
QJM. 2018 Jan 1;111(1):39-45. doi: 10.1093/qjmed/hcx194.
2
Position paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis.立场文件:2017 年关于肉芽肿性多血管炎和显微镜下多血管炎抗中性粒细胞胞浆抗体检测的国际共识修订版。
Nat Rev Rheumatol. 2017 Nov;13(11):683-692. doi: 10.1038/nrrheum.2017.140. Epub 2017 Sep 14.
3
A case of massive aortic mural thrombus in the absence of atherosclerotic or aneurysmal disease.
一例无动脉粥样硬化或动脉瘤性疾病的主动脉壁巨大血栓形成病例。
Int J Cardiol Heart Vasc. 2016 Aug 4;12:82-84. doi: 10.1016/j.ijcha.2016.07.003. eCollection 2016 Sep.
4
Progressive Bilateral Facial Palsy as a Manifestation of Granulomatosis With Polyangiitis: A Case Report.进行性双侧面神经麻痹作为肉芽肿性多血管炎的一种表现:病例报告
Ann Rehabil Med. 2016 Aug;40(4):734-40. doi: 10.5535/arm.2016.40.4.734. Epub 2016 Aug 24.
5
Granulomatosis with polyangiitis and facial palsy: Literature review and insight in the autoimmune pathogenesis.肉芽肿性多血管炎伴面瘫:文献复习及自身免疫发病机制的探讨。
Autoimmun Rev. 2016 Jul;15(7):621-31. doi: 10.1016/j.autrev.2016.02.005. Epub 2016 Feb 4.
6
Choosing wisely: Review and commentary on anti-nuclear antibody (ANA) testing.明智选择:抗核抗体(ANA)检测的回顾与评论。
Autoimmun Rev. 2016 Mar;15(3):272-80. doi: 10.1016/j.autrev.2015.12.002. Epub 2015 Dec 11.
7
Thrombosis in vasculitis: from pathogenesis to treatment.血管炎中的血栓形成:从发病机制到治疗
Thromb J. 2015 Apr 16;13:15. doi: 10.1186/s12959-015-0047-z. eCollection 2015.
8
Choosing wisely: the American College of Rheumatology's Top 5 list of things physicians and patients should question.明智选择:美国风湿病学会列出的医生和患者应质疑的前五件事。
Arthritis Care Res (Hoboken). 2013 Mar;65(3):329-39. doi: 10.1002/acr.21930.
9
Bilateral facial nerve palsy: a diagnostic dilemma.双侧面神经麻痹:诊断难题。
Case Rep Emerg Med. 2012;2012:458371. doi: 10.1155/2012/458371. Epub 2012 Jan 23.
10
Wegener's granulomatosis in primary care.基层医疗中的韦格纳肉芽肿病。
JRSM Short Rep. 2010 Dec 6;1(7):59. doi: 10.1258/shorts.2010.010100.