免疫功能低下个体中导致菌血症的差异基因表达谱。
Differential gene expression profile of causing bacteremia in an immunocompromised individual.
作者信息
Muthuirulandi Sethuvel Dhiviya Prabaa, Devanga Ragupathi Naveen Kumar, Ninan Marilyn M, Michael Joy Sarojini, Anandan Shalini, Veeraraghavan Balaji
机构信息
Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.
出版信息
Future Sci OA. 2020 Jan 29;6(4):FSO456. doi: 10.2144/fsoa-2019-0117.
AIM
species has varying levels of virulence gene expression with respect to different sites of infection. In this study, the differential gene expression of in response to its site of infection was analyzed by transcriptomics.
METHODS
This study includes four clinical isolates. Transcriptomics was done for the stool and blood samples of a single patient. Isolates were screened for the presence of antimicrobial resistance genes.
RESULTS
The majority of genes involved in invasion were highly expressed in the strain isolated from the primary site of infection. Additionally, antimicrobial resistance (1A, II, . and S) genes were identified.
CONCLUSION
This study provides a concise view of the transcriptional expression of clinical strains and provides a basis for future functional studies on spp.
目的
某物种针对不同感染部位具有不同水平的毒力基因表达。在本研究中，通过转录组学分析了[具体物种]响应其感染部位的差异基因表达。
方法
本研究纳入了4株临床[具体物种]分离株。对一名患者的粪便和血液样本进行了转录组学分析。对分离株进行抗菌抗性基因筛查。
结果
大多数参与侵袭的基因在从感染原发部位分离出的菌株中高表达。此外，还鉴定出了抗菌抗性（1A、II、[具体基因]和S）基因。
结论
本研究提供了临床菌株转录表达的简要概况，并为未来关于[具体物种]属的功能研究提供了基础。
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