Institut Pasteur, Unité des Interactions Bactéries-Cellules, Département de Biologie Cellulaire et Infection, F-75015 Paris, France; INSERM, U604, F-75015 Paris, France; INRA, USC2020, F-75015 Paris, France.
Microbes Infect. 2015 Mar;17(3):173-83. doi: 10.1016/j.micinf.2015.01.004. Epub 2015 Jan 29.
Bacterial pathogens have evolved a wide range of strategies to colonize and invade human organs, despite the presence of multiple host defense mechanisms. In this review, we will describe how pathogenic bacteria can adhere and multiply at the surface of host cells, how some bacteria can enter and proliferate inside these cells, and finally how pathogens may cross epithelial or endothelial host barriers and get access to internal tissues, leading to severe diseases in humans.
细菌病原体尽管面临多种宿主防御机制，但已进化出广泛的策略来定殖和侵袭人体器官。在这篇综述中，我们将描述致病性细菌如何在宿主细胞表面黏附和繁殖，某些细菌如何进入和在这些细胞内增殖，以及病原体最终如何穿过上皮或内皮宿主屏障并进入内部组织，导致人类严重疾病。
