Lo Pei-Chia, Lin Shun-Ku, Lai Jung-Nien
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, No.155, Sec.2, Linong St, Beitou Dist, Taipei City, Taiwan.
Taiwan Association for Traditional Chinese Medicine of Family, 9F, No.105, Yusheng St, Shilin Dist, Taipei City, Taiwan.
J Tradit Complement Med. 2019 Apr 23;10(2):141-149. doi: 10.1016/j.jtcme.2019.04.005. eCollection 2020 Mar.
Clinical trials have indicated some traditional Chinese medicine formulas reduce airway hyperresponsiveness and relieve asthma symptoms. This study investigated Chinese herbal Medicine (CHM) for childhood asthma and clarified the relationship between CHM use and consequent asthma hospitalization by a population-based cohort study.
We used the data of one million individuals randomly selected from Registry of Beneficiaries of the National Health Insurance Research Database. Patients aged less than 18 years and diagnosed as asthma were followed from 2000 to 2012 and divided into the CHM group and the non-CHM group. Cox proportional hazard regression model was conducted to estimate the adjusted hazard ratio (aHR) of the two groups, and the Kaplan-Meier survival curve was used to determine the association between CHM cumulative days and consequent asthma hospitalization.
Of the total of 33,865 patients, 14,783 (43.6%) were included in the CHM group, and 19,082 (56.4%) were included in the non-CHM group. After adjustment for gender, age, comorbidities, and total numbers of asthma medication, CHM users had a lower risk of asthma hospitalization than non-CHM users (aHR: 0.90, 95% confidence interval [CI]: 0.83-0.95). Children older than 6 years who used CHM therapy for more than 180 days exhibited a reduction of 29% for the risk of consequent asthma hospitalization (aHR: 0.71, 95% CI: 0.51-0.98).
Children aged 6-18 years who used more than 6 months CHM therapy reduced the risk of consequent asthma hospitalization. Long-term CHM therapy has benefit in school-age children with asthma.
临床试验表明，一些中药配方可降低气道高反应性并缓解哮喘症状。本研究通过一项基于人群的队列研究，对儿童哮喘的中药治疗进行了调查，并阐明了使用中药与随后哮喘住院之间的关系。
我们使用了从国民健康保险研究数据库受益登记处随机抽取的100万人的数据。对2000年至2012年期间年龄小于18岁且被诊断为哮喘的患者进行随访，并分为中药组和非中药组。采用Cox比例风险回归模型估计两组的调整后风险比（aHR），并使用Kaplan-Meier生存曲线确定中药累积使用天数与随后哮喘住院之间的关联。
在总共33,865名患者中，14,783名（43.6%）被纳入中药组，19,082名（56.4%）被纳入非中药组。在对性别、年龄、合并症和哮喘药物总数进行调整后，使用中药的患者哮喘住院风险低于未使用中药的患者（aHR：0.90，95%置信区间[CI]：0.83-0.95）。6岁以上使用中药治疗超过180天的儿童，随后哮喘住院风险降低了29%（aHR：0.71，95%CI：0.51-0.98）。
6至18岁使用中药治疗超过6个月的儿童降低了随后哮喘住院的风险。长期中药治疗对学龄期哮喘儿童有益。
