Rajizadeh Mohammad Amin, Najafipour Hamid, Bejeshk Mohammad Abbas
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Science, Kerman, Iran.
Evid Based Complement Alternat Med. 2024 Feb 8;2024:5373117. doi: 10.1155/2024/5373117. eCollection 2024.
Asthma is a common disease with rising prevalence worldwide, especially in industrialized countries. Current asthma therapy with traditional medicines lacks satisfactory success, hence the patients' search for alternative and complementary treatments for their diseases. Researchers have conducted many studies on plants with antiallergic and antiasthmatic effects in recent decades. Many of these plants are now used in clinics, and searching for their mechanism of action may result in creating new ideas for producing more effective drugs.
The goal of this review was to provide a compilation of the findings on plants and their active agents with experimentally confirmed antiasthmatic effects. . A literature search was conducted from 1986 to November 2023 in Scopus, Springer Link, EMBASE, Science Direct, PubMed, Google Scholar, and Web of Science to identify and report the accumulated knowledge on herbs and their compounds that may be effective in asthma treatment.
The results revealed that 58 plants and 32 herbal extracted compounds had antiasthmatic activity. Also, 32 plants were shown to have anti-inflammatory and antioxidative effects or may act as bronchodilators and potentially have antiasthmatic effects, which must be investigated in future studies.
The ability of herbal medicine to improve asthma symptoms has been confirmed by clinical and preclinical studies, and such compounds may be used as a source for developing new antiasthmatic drugs. Moreover, this review suggests that many bioactive compounds have therapeutic potential against asthma.
哮喘是一种常见疾病，在全球范围内患病率呈上升趋势，尤其是在工业化国家。目前使用传统药物治疗哮喘的效果不尽人意，因此患者寻求针对其疾病的替代和补充治疗方法。近几十年来，研究人员对具有抗过敏和抗哮喘作用的植物进行了许多研究。现在许多这类植物已应用于临床，探究其作用机制可能会为开发更有效的药物带来新的思路。
本综述的目的是汇编有关具有经实验证实的抗哮喘作用的植物及其活性剂的研究结果。在Scopus、Springer Link、EMBASE、Science Direct、PubMed、谷歌学术和科学网中进行了从1986年至2023年11月的文献检索，以识别和报告有关可能对哮喘治疗有效的草药及其化合物的累积知识。
结果显示，58种植物和32种草药提取物化合物具有抗哮喘活性。此外，有32种植物显示具有抗炎和抗氧化作用，或可能起到支气管扩张剂的作用并潜在具有抗哮喘作用，这必须在未来的研究中进行调查。
临床和临床前研究已证实草药改善哮喘症状的能力，此类化合物可用作开发新型抗哮喘药物的来源。此外，本综述表明许多生物活性化合物具有抗哮喘的治疗潜力。
