转移性前列腺癌患者身体成分与雄激素剥夺治疗激素敏感性之间的关系。
Relationship between body composition and hormone sensitivity for androgen deprivation therapy in patients with metastatic prostate cancer.
作者信息
Kashiwagi Eiji, Shiota Masaki, Masaoka Hiroyuki, Imada Kenjiro, Monji Keisuke, Takeuchi Ario, Inokuchi Junichi, Tatsugami Katsunori, Eto Masatoshi
机构信息
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Japan.
出版信息
Prostate Int. 2020 Mar;8(1):22-26. doi: 10.1016/j.prnil.2019.11.002. Epub 2019 Nov 30.
BACKGROUND
To evaluate the relationship between body composition and the oncological outcome of androgen deprivation therapy (ADT), we investigated whether body composition features including the psoas muscle may be predictive factors of ADT.
METHODS
This study enrolled patients with hormone-naïve metastatic prostate cancer who were treated with primary ADT from April 1996 to November 2013 at Kyushu University Hospital and who underwent a computed tomography scan before primary ADT for calculating body fat percentage, psoas muscle ratio (psoas muscle, cm/height, cm), and body mass index.
RESULTS
Of the 178 patients enrolled, 60 patients died during follow-up. Median follow-up was 32 months, and progression-free survival and overall survival (OS) were 28 and 80 months, respectively. Multivariate analysis revealed that the psoas muscle ratio was correlated with OS (hazard ratio: 0.448; 95% confidence interval = 0.206-0.922; = 0.028).
CONCLUSIONS
This study demonstrated that higher psoas muscle ratio predicts longer OS among patients with nonlocalized prostate cancer treated with primary ADT.
背景
为了评估身体组成与雄激素剥夺治疗（ADT）的肿瘤学结局之间的关系，我们研究了包括腰大肌在内的身体组成特征是否可能是ADT的预测因素。
方法
本研究纳入了1996年4月至2013年11月在九州大学医院接受初始ADT治疗的激素初治转移性前列腺癌患者，这些患者在初始ADT之前接受了计算机断层扫描，以计算体脂百分比、腰大肌比率（腰大肌，厘米/身高，厘米）和体重指数。
结果
在纳入的178例患者中，60例患者在随访期间死亡。中位随访时间为32个月，无进展生存期和总生存期（OS）分别为28个月和80个月。多变量分析显示，腰大肌比率与OS相关（风险比：0.448；95%置信区间=0.206-0.922；P=0.028）。
结论
本研究表明，在接受初始ADT治疗的非局限性前列腺癌患者中，较高的腰大肌比率预示着更长的OS。
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