Zhang Zheng-Rong, Wu Jian, Li Han-Wen, Wang Tao
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241000, Anhui Province, China.
World J Clin Cases. 2020 Mar 26;8(6):1164-1171. doi: 10.12998/wjcc.v8.i6.1164.
The aim of the present study was to examine the clinical characteristics of hepatoid adenocarcinoma of the stomach (HAS) and its diagnosis, treatment, and prognosis.
A retrospective analysis of 13 HAS cases was performed. The mean age of the 13 patients was 66.08 years, and 10 of the 13 patients were male. Prior to treatment, the alpha-fetoprotein levels in the serum were elevated in 7 patients, the tumour was located in the distal or gastric body in 11 patients, and the gastroscopy pathological results showed that 3 patients had poorly differentiated tumours and that 8 patients had moderately/poorly differentiated tumours. Abdominal CT scans showed local stomach wall thickening, and enlarged lymph nodes were visible around the stomach in 8 patients. Of the 13 patients, 11 underwent radical surgery. The clinical pathological staging was as follows: Stage II in 2 cases; stage III in 8 cases; and stage IV in 1 case. A total of 3 patients were lost to follow-up. Otherwise, as of the last follow-up, 3 patients had survived for 56 mo, and the other 7 patients failed to achieve long-term survival (survival period of 1-56 mo).
HAS is a special type of gastric cancer, and the prognosis of HAS has improved compared with past prognoses. Measurement of alpha-fetoprotein, early diagnosis, active surgical treatment, and application of new diagnostic and treatment techniques are conducive to improving the prognosis of HAS.
本研究旨在探讨胃肝样腺癌(HAS)的临床特征及其诊断、治疗和预后。
对13例HAS病例进行回顾性分析。13例患者的平均年龄为66.08岁,其中10例为男性。治疗前,7例患者血清甲胎蛋白水平升高,11例患者肿瘤位于胃远端或胃体部,胃镜病理结果显示3例患者为低分化肿瘤,8例患者为中/低分化肿瘤。腹部CT扫描显示胃壁局部增厚,8例患者胃周可见肿大淋巴结。13例患者中,11例行根治性手术。临床病理分期如下:Ⅱ期2例;Ⅲ期8例;Ⅳ期1例。共有3例患者失访。否则,截至最后一次随访,3例患者存活56个月,其他7例患者未实现长期生存(生存期1 - 56个月)。
HAS是一种特殊类型的胃癌,与过去的预后相比,HAS的预后有所改善。检测甲胎蛋白、早期诊断、积极手术治疗以及应用新的诊断和治疗技术有利于改善HAS的预后。