Department of Oncology, Qingdao Municipal Hospital, Qingdao 266011, China.
Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Biomed Res Int. 2020 Mar 18;2020:9390878. doi: 10.1155/2020/9390878. eCollection 2020.
Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality worldwide. To date, chemotherapy plays an important role in the treatment of CRC patients. Multidrug resistance (MDR) is one of the major hurdles in chemotherapy for CRC, and the underlying mechanisms need to be explored. Studies have demonstrated that Wnt/-catenin signaling plays a critical role in oncogenesis and tumor development, and its function in inhibiting apoptosis could facilitate tumor chemoresistance. Recent investigations have also suggested the regulatory effects of the Wnt/-catenin signaling pathway in response to chemotherapeutic agents in CRC. Here, we particularly focus on reviewing the evidences suggesting the mechanisms of Wnt/-catenin signaling in the chemoresistance modulation of colorectal cancer.
结直肠癌（CRC）是一种常见的恶性肿瘤，在全球范围内具有较高的发病率和死亡率。迄今为止，化疗在 CRC 患者的治疗中发挥着重要作用。多药耐药（MDR）是 CRC 化疗的主要障碍之一，需要探索其潜在机制。研究表明，Wnt/-catenin 信号通路在肿瘤发生和肿瘤发展中起着关键作用，其抑制细胞凋亡的功能有助于肿瘤的化疗耐药性。最近的研究还表明，Wnt/-catenin 信号通路在 CRC 对化疗药物的反应中具有调节作用。在这里，我们特别关注综述 Wnt/-catenin 信号在结直肠癌细胞耐药性调节中的作用机制的证据。
