Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, United Kingdom.
Semin Cancer Biol. 2019 Oct;58:65-79. doi: 10.1016/j.semcancer.2019.01.001. Epub 2019 Jan 8.
Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on insights gleaned from almost a quarter century of research, it is obvious that deregulation of spatio-temporally controlled signaling pathways play instrumental role in development and progression of colorectal cancer. High-throughput technologies have helped to develop a sharper and broader understanding of the wide ranging signal transduction cascades which also contribute to development of drug resistance, loss of apoptosis and, ultimately, of metastasis. In this review, we have set the spotlight on role of JAK/STAT, TGF/SMAD, Notch, WNT/β-Catenin, SHH/GLI and p53 pathways in the development and progression of colorectal cancer. We have also highlighted recent reports on TRAIL-mediated pathways and molecularly distinct voltage-gated sodium channels in colorectal cancer.
结直肠癌是一种多方面的疾病，在治疗上具有挑战性。基于近四分之一世纪的研究获得的见解，很明显，时空控制信号通路的失调在结直肠癌的发生和发展中起着重要作用。高通量技术有助于更深入、更广泛地了解广泛的信号转导级联反应，这些反应也有助于耐药性的发展、细胞凋亡的丧失，最终导致转移。在这篇综述中，我们重点介绍了 JAK/STAT、TGF/SMAD、Notch、WNT/β-Catenin、SHH/GLI 和 p53 通路在结直肠癌发生和发展中的作用。我们还强调了最近关于 TRAIL 介导的途径和分子上不同的电压门控钠离子通道在结直肠癌中的报告。
