Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410081, China.
Department of Social Medicine and Health Management, School of Medicine, Hunan Normal University, Changsha 410081, China.
J Diabetes Res. 2020 Mar 5;2020:3251275. doi: 10.1155/2020/3251275. eCollection 2020.
Emerging studies have explored the association between the famine exposure during early life and the risk of the metabolic syndrome, and the results remain controversial. This meta-analysis was performed to summarize the famine effects on the prevalence of metabolic syndrome (MetS) in adulthood. We searched the PubMed, Web of Science, Embase, ScienceDirect, and Chinese National Knowledge Infrastructure for relevant studies up to December 2019. Pooled odd ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the effect exposure to famine on MetS using a random-effects model, and the was used to evaluate the heterogeneity.
The analyses included 39 studies from 10 articles with a total of 81504 participants. Fourteen studies from 10 articles for fetal famine exposure, 20 studies from 7 articles for childhood famine exposure, and 5 studies from 3 articles for adolescence/adult famine exposure were included in this meta-analysis. Compared with a nonexposed group, famine exposure significantly increased the risk of MetS for early life famine exposure (OR = 1.27, 95% CI: 1.18-1.38), fetal famine exposure (OR = 1.27, 95% CI: 1.14-1.43), and childhood famine exposure (OR = 1.29, 95% CI: 1.16-1.44). Subgroup analyses showed that the result was consistent regardless of the study designs, definitions of MetS, and causes of famine, with or without adjustment for age, smoking, drinking, and physical activity.
This meta-analysis suggests that exposure to famine during early life may increase the risk of MetS in adulthood.
越来越多的研究探讨了生命早期饥荒暴露与代谢综合征风险之间的关系，但结果仍存在争议。本荟萃分析旨在总结饥荒对成年人代谢综合征（MetS）患病率的影响。我们检索了PubMed、Web of Science、Embase、ScienceDirect 和中国知网，截至 2019 年 12 月，检索到相关研究。使用随机效应模型，用合并的比值比（OR）及其 95%置信区间（CI）来评估暴露于饥荒对 MetS 的影响，并用 Q 检验评估异质性。
分析共纳入 10 篇文献中的 39 项研究，共计 81504 名参与者。10 篇文献中的 14 项研究纳入胎儿期饥荒暴露，7 篇文献中的 20 项研究纳入儿童期饥荒暴露，3 篇文献中的 5 项研究纳入青春期/成年期饥荒暴露。与未暴露组相比，早期生命饥荒暴露（OR=1.27，95%CI：1.18-1.38）、胎儿期饥荒暴露（OR=1.27，95%CI：1.14-1.43）和儿童期饥荒暴露（OR=1.29，95%CI：1.16-1.44）显著增加了 MetS 的患病风险。亚组分析表明，无论研究设计、MetS 定义和饥荒原因如何，是否调整年龄、吸烟、饮酒和体力活动，结果都是一致的。
本荟萃分析表明，生命早期暴露于饥荒可能会增加成年后患 MetS 的风险。
