Premo Julie E, Liu Yanni, Bilek Emily L, Phan K Luan, Monk Christopher S, Fitzgerald Kate D
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH 43210, USA.
J Psychiatr Brain Sci. 2020;5. doi: 10.20900/jpbs.20200005. Epub 2020 Feb 28.
In the following grant report, we describe initial and planned work supported by our National Institute of Mental Health R01-funded, Research Domain Criteria (RDoc) informed project, "Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety". This project examines response to cognitive behavioral therapy (CBT) in a large sample of anxiety-affected and low-anxious youth ages 7 to 18 years using multiple levels of analysis, including brain imaging, behavioral performance, and clinical measures. The primary goal of the project is to understand how brain-behavioral markers of anxiety-relevant constructs, namely acute threat, cognitive control, and their interaction, associate with CBT response in youth with clinically significant anxiety. A secondary goal is to determine whether child age influences how these markers predict, and/or change, across varying degrees of CBT response. Now in its fourth year, data from this project has informed the examination of (1) baseline (i.e., pre-CBT) anxiety severity as a function of brain-behavioral measures of cognitive control, and (2) clinical characteristics of youth and parents that associate with anxiety severity and/or predict response to CBT. Analysis of brain-behavioral markers before and after CBT will assess mechanisms of CBT effect, and will be conducted once the data collection in the full sample has been completed. This knowledge will help guide the treatment of clinically anxious youth by informing for whom and how does CBT work.
在以下资助报告中，我们描述了由美国国立精神卫生研究所R01资助的、基于研究领域标准（RDoc）的项目“儿童焦虑症认知行为疗法（CBT）结果的维度脑行为预测指标”所支持的初始工作和计划工作。该项目使用多种分析层面，包括脑成像、行为表现和临床测量，对大量7至18岁受焦虑影响和低焦虑的青少年样本进行认知行为疗法（CBT）反应的研究。该项目的主要目标是了解焦虑相关结构的脑行为标记，即急性威胁、认知控制及其相互作用，如何与临床上有显著焦虑的青少年的CBT反应相关联。次要目标是确定儿童年龄是否会影响这些标记在不同程度的CBT反应中的预测和/或变化方式。该项目现已进入第四年，其数据为以下研究提供了信息：（1）作为认知控制的脑行为测量指标的函数的基线（即CBT前）焦虑严重程度，以及（2）与焦虑严重程度相关联和/或预测CBT反应的青少年和父母的临床特征。对CBT前后脑行为标记的分析将评估CBT效果的机制，并且将在全样本的数据收集完成后进行。这些知识将通过告知CBT对谁有效以及如何有效，来帮助指导临床上焦虑青少年的治疗。
