Braga Carlos Galvão, Rodrigues Ana Raquel, Alves Marina, Portela Catarina, Pinto Luísa, Marques Herlander
Serviço de Medicina Interna, Hospital de Braga, Braga, Portugal.
Serviço de Oncologia, Hospital de Braga, Braga, Portugal.
Porto Biomed J. 2016 May-Jun;1(2):49-51. doi: 10.1016/j.pbj.2016.04.001. Epub 2016 Jun 19.
Plasma cell leukaemia (PCL) is a rare and aggressive disease. Diagnosis is made when there are >2000/#mL circulating plasma cells in peripheral blood or plasmacytosis >20% of total leukocyte count. We report a case of a 51-year old man with generalized bone pain and constitutional symptoms. Blood peripheral smear revealed leukocytosis with 39% plasma cells. Bone marrow biopsy showed plasma cell invasion, which confirmed the diagnosis of PCL. Additionally, the patient had markers of advanced disease. Chemotherapy with vincristine, adriamycin and dexamethasone was started. Despite an initial favourable response, the patient died 2 months later due to an infectious complication. PCL has no established treatment and has a dismal prognosis, requiring the achievement of better data to improve the disease course.
浆细胞白血病（PCL）是一种罕见的侵袭性疾病。当外周血中循环浆细胞>2000/μL或浆细胞增多症占白细胞总数的>20%时可作出诊断。我们报告一例51岁男性，有全身骨痛和全身症状。外周血涂片显示白细胞增多，浆细胞占39%。骨髓活检显示浆细胞浸润，确诊为PCL。此外，该患者有晚期疾病标志物。开始使用长春新碱、阿霉素和地塞米松进行化疗。尽管最初反应良好，但患者2个月后因感染性并发症死亡。PCL尚无既定的治疗方法，预后不佳，需要获取更好的数据以改善病程。
