The inter-dependence of basic and applied biomedical sciences: Lessons from kidney development and tissue-engineering.
作者信息
Davies Jamie A
机构信息
University of Edinburgh Medical School Edinburgh, Scotland, UK.
出版信息
Porto Biomed J. 2017 Sep-Oct;2(5):136-139. doi: 10.1016/j.pbj.2017.05.003. Epub 2017 Sep 1.
Abstract
摘要
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本文引用的文献
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Development of the Mammalian Kidney.哺乳动物肾脏的发育
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Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.人诱导多能干细胞来源的肾类器官包含多种细胞谱系，并可模拟人类肾发生。
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Nephrons require Rho-kinase for proximal-distal polarity development.肾单位在近端-远端极性发育过程中需要Rho激酶。
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An improved method of renal tissue engineering, by combining renal dissociation and reaggregation with a low-volume culture technique, results in development of engineered kidneys complete with loops of Henle.通过将肾组织分离和再聚集与小体积培养技术相结合，改进了肾脏组织工程方法，可构建具有 Henle 袢的工程化肾脏。
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An improved kidney dissociation and reaggregation culture system results in nephrons arranged organotypically around a single collecting duct system.改良的肾脏分离再聚合培养系统使得肾单位围绕单个集合管系统呈器官样排列。
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