糖尿病肾病和非糖尿病肾病患者的血压及血磷水平：横断面“低清除率会诊”研究结果
Blood pressure and phosphate level in diabetic and non-diabetic kidney disease: Results of the cross-sectional "Low Clearance Consultation" study.
作者信息
Mendes Margarida, Resende Luis, Teixeira Alves, Correia João, Silva Gil
机构信息
SESARAM, Bom Jesus Health Centre, Madeira, Portugal.
SESARAM, Nephrology Department, Madeira, Portugal.
出版信息
Porto Biomed J. 2017 Nov-Dec;2(6):301-305. doi: 10.1016/j.pbj.2017.02.005. Epub 2017 Mar 30.
HIGHLIGHTS
A statistically significant and moderate positive correlation was verified between systolic blood pressure and plasma phosphate concentration in the whole sample (diabetic and non-diabetic), due to the diabetic chronic kidney disease group.A statistically significant and moderate positive correlation was verified between the diastolic blood pressure and plasma phosphate concentration in the whole sample (diabetic and non-diabetic), due to the diabetic chronic kidney disease group.A statistically significant and strong negative correlation was found between diastolic blood pressure and estimated glomerular filtration rate in the diabetic chronic kidney disease group, but there was no statistically significant correlation in the whole sample (diabetic and non-diabetic).
ABSTRACT
Diabetic kidney disease features certain clinical and laboratorial characteristics that differ from chronic kidney disease of other etiologies. We performed a transversal study comparing some of these characteristics and assessed potential associations among blood pressure, plasma phosphate concentration and estimated glomerular filtration rate between patients with diabetic and non-diabetic chronic kidney disease.We found a positive correlation between both systolic and diastolic blood pressure and the plasma phosphate concentration in the diabetic kidney disease group, but not in the non-diabetic group. Also, diastolic blood pressure was negatively correlated with the estimated glomerular filtration rate in the diabetic group, yet not in the non-diabetic group.In conclusion, these data support the hypothesis of a close link between systolic and diastolic blood pressure and hyperphosphatemia, as well as between diastolic blood pressure and estimated glomerular filtration rate, in patients with diabetic kidney disease. Therapeutic approaches directed at these factors might prove to be important to delay the decline of renal function in the subgroup of patients with diabetic kidney disease.
要点
在整个样本（糖尿病患者和非糖尿病患者）中，由于糖尿病慢性肾病组的存在，收缩压与血浆磷酸盐浓度之间证实存在统计学显著且中等程度的正相关。在整个样本（糖尿病患者和非糖尿病患者）中，由于糖尿病慢性肾病组的存在，舒张压与血浆磷酸盐浓度之间证实存在统计学显著且中等程度的正相关。在糖尿病慢性肾病组中，舒张压与估计肾小球滤过率之间发现存在统计学显著且强的负相关，但在整个样本（糖尿病患者和非糖尿病患者）中无统计学显著相关性。
摘要
糖尿病肾病具有某些不同于其他病因慢性肾病的临床和实验室特征。我们进行了一项横断面研究，比较其中一些特征，并评估糖尿病和非糖尿病慢性肾病患者之间血压、血浆磷酸盐浓度和估计肾小球滤过率之间的潜在关联。我们发现糖尿病肾病组的收缩压和舒张压与血浆磷酸盐浓度均呈正相关，但非糖尿病组未出现这种情况。此外，糖尿病组的舒张压与估计肾小球滤过率呈负相关，而非糖尿病组未出现这种情况。总之，这些数据支持以下假设：糖尿病肾病患者的收缩压和舒张压与高磷血症之间以及舒张压与估计肾小球滤过率之间存在密切联系。针对这些因素的治疗方法可能对延缓糖尿病肾病患者亚组的肾功能下降具有重要意义。
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