顶叶癫痫的发作间期脑磁图——等效电流偶极子与波束形成器（SAMepi）分析的比较
Interictal magnetoencephalography in parietal lobe epilepsy - Comparison of equivalent current dipole and beamformer (SAMepi) analysis.
作者信息
Wilenius Juha, Lauronen Leena, Kirveskari Erika, Gaily Eija, Metsähonkala Liisa, Paetau Ritva
机构信息
HUS Medical Imaging Center, Clinical Neurophysiology, University of Helsinki and Helsinki University Hospital, Finland.
HUS Medical Imaging Center, BioMag Laboratory, University of Helsinki and Helsinki University Hospital, Finland.
出版信息
Clin Neurophysiol Pract. 2020 Mar 10;5:64-72. doi: 10.1016/j.cnp.2020.02.003. eCollection 2020.
OBJECTIVE
To evaluate a novel analysis method (SAMepi) in the localization of interictal epileptiform magnetoencephalographic (MEG) activity in parietal lobe epilepsy (PLE) patients in comparison with equivalent current dipole (ECD) analysis.
METHODS
We analyzed the preoperative interictal MEG of 17 operated PLE patients utilizing visual analysis and: (1) ECD with a spherical conductor model; (2) ECD with a boundary element method (BEM) conductor model; and (3) SAMepi - a kurtosis beamformer method. Localization results were compared between the three methods, to the location of the resection and to the clinical outcome.
RESULTS
Fourteen patients had an epileptiform finding in the visual analysis; SAMepi detected spikes in 11 of them. A unifocal finding in both the ECD and in the SAMepi analysis was associated with a better chance of seizure-freedom (p = 0.02). There was no significant difference in the distances from the unifocal MEG localizations to the nearest border of the resection between the different analysis methods.
CONCLUSIONS
Localizations of unifocal interictal spikes detected by SAMepi did not significantly differ from the conventional ECD localizations.
SIGNIFICANCE
SAMepi - a novel semiautomatic analysis method - is useful in localizing interictal epileptiform MEG activity in the presurgical evaluation of parietal lobe epilepsy patients.
目的
与等效电流偶极子（ECD）分析相比，评估一种用于定位顶叶癫痫（PLE）患者发作间期癫痫样脑磁图（MEG）活动的新型分析方法（SAMepi）。
方法
我们对17例接受手术的PLE患者术前发作间期的MEG进行了分析，采用了视觉分析以及：（1）基于球形导体模型的ECD；（2）基于边界元法（BEM）导体模型的ECD；以及（3）SAMepi——一种峰度波束形成器方法。比较了这三种方法之间以及与切除部位和临床结果的定位结果。
结果
14例患者在视觉分析中有癫痫样表现；SAMepi在其中11例中检测到尖峰。ECD和SAMepi分析中的单灶性表现与无癫痫发作的更好机会相关（p = 0.02）。不同分析方法中，单灶性MEG定位到切除最近边界的距离无显著差异。
结论
SAMepi检测到的单灶性发作间期尖峰的定位与传统ECD定位无显著差异。
意义
SAMepi——一种新型半自动分析方法——在顶叶癫痫患者术前评估中定位发作间期癫痫样MEG活动方面很有用。
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