Martínez-Leal Bernardo, Álvarez-Banderas Karla Ivette, Sánchez-Dávila Homero, Dávila-Rodríguez Martha Imelda, Cortés-Gutiérrez Elva Irene
Universidad de Monterrey, Vicerrectoría Ciencias de la Salud, San Pedro Garza García, México.
Department of Clinical Dysplasia, Gynecology and Obstetrics No.23 Hospital, Mexican Institute of Social Security, Monterrey, Mexico.
Int J Reprod Biomed. 2020 Feb 27;18(2):129-134. doi: 10.18502/ijrm.v18i2.6433. eCollection 2020 Feb.
The role of human papillomavirus (HPV) as single or multiple infections in pregnant women would be relevant to determine the time to progression and/or the time to regression of cervical lesions.
In this preliminary study, we determined the prevalence of HPV as single or multiple infections in pregnant women from Northeastern Mexico.
Samples from 31 pregnant and 62 nonpregnant women were examined between January 2015 and November 2015 at UMAE-23 of the Instituto Mexicano del Seguro Social (IMSS). The samples of cervicovaginal exudate were obtained for HPV DNA detection using the INNO-LiPA test, and HPV infections were analyzed as single or multiple infections. Participants completed a questionnaire on sociodemographic, gynecological, obstetric, and sexual behavior characteristics.
The mean age of the pregnant women was 25.7 4.8 yr, with an average time of pregnancy of 6 1 months at the time of the study. With respect to age, parity, smoking history, or oral contraceptive use no statistically significant differences between the two studied groups was observed. The HPV infection was 2.7 times higher in pregnant women (35%) than in the control group (13%). In total, 78% of the pregnant women who were HPV-positive presented with single infections compared with 28% of the nonpregnant women.
A higher prevalence of HPV as a single infection was found in this sample of pregnant Mexican women. Follow-up is necessary to evaluate the persistence or regression of the infection.
人乳头瘤病毒（HPV）作为单一感染或多重感染在孕妇中的作用，对于确定宫颈病变进展时间和/或消退时间至关重要。
在这项初步研究中，我们确定了墨西哥东北部孕妇中HPV单一感染或多重感染的患病率。
2015年1月至2015年11月期间，在墨西哥社会保险局（IMSS）的UMAE - 23对31名孕妇和62名非孕妇进行了样本检测。采集宫颈阴道分泌物样本，使用INNO - LiPA检测法进行HPV DNA检测，并将HPV感染分析为单一感染或多重感染。参与者完成了一份关于社会人口统计学、妇科、产科和性行为特征的问卷。
孕妇的平均年龄为25.7±4.8岁，研究时平均怀孕时间为6±1个月。在年龄、产次、吸烟史或口服避孕药使用方面，两个研究组之间未观察到统计学上的显著差异。孕妇的HPV感染率（35%）比对照组（13%）高2.7倍。总体而言，HPV阳性的孕妇中有78%为单一感染，而非孕妇中这一比例为28%。
在这一样本的墨西哥孕妇中，发现HPV单一感染的患病率较高。有必要进行随访以评估感染的持续或消退情况。
