Shaker Ahmed M M, Abdelall Eman K A, Abdellatif Khaled R A, Abdel-Rahman Hamdy M
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni-Suef, 62517 Egypt.
2Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514 Egypt.
BMC Chem. 2020 Mar 30;14(1):23. doi: 10.1186/s13065-020-00675-5. eCollection 2020 Dec.
Three series of 2-(4-methylsulfonylphenyl) indole derivatives have been designed and synthesized. The synthesized compounds were assessed for their antimicrobial, COX inhibitory and anti-inflammatory activities. Compound was identified to be the most potent antibacterial candidate against strains of , and , respectively, with safe therapeutic dose. Compounds and showed good anti-inflammatory activity with excessive selectivity towards COX-2 in comparison with reference drugs indomethacin and celecoxib. Compounds were found to release moderate amounts of NO to decrease the side effects associated with selective COX-2 inhibitors. A molecular modeling study for compounds and into COX-2 active site was correlated with the results of in vitro COX-2 inhibition assays.
已设计并合成了三组2-(4-甲基磺酰基苯基)吲哚衍生物。对合成的化合物进行了抗菌、COX抑制和抗炎活性评估。化合物被确定为分别对、和菌株最有效的抗菌候选物，且治疗剂量安全。与参比药物吲哚美辛和塞来昔布相比，化合物和显示出良好的抗炎活性，对COX-2具有高度选择性。发现化合物释放适量的NO以减少与选择性COX-2抑制剂相关的副作用。对化合物和进入COX-2活性位点的分子模拟研究与体外COX-2抑制试验结果相关。
