黄河鲟促肾上腺皮质激素释放因子系统转录水平与摄食状态的关系。
Changes in corticotropin releasing factor system transcript levels in relation to feeding condition in Acipenser dabryanus.
机构信息
Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, 211# Huimin Road, Chengdu, Sichuan, China.
Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, 211# Huimin Road, Chengdu, Sichuan, China; The Key Laboratory of Mariculture, Ministry of Education, Fisheries College, Ocean University of China, 5# Yushan Road, Qingdao, Shandong, China.
出版信息
Peptides. 2020 Jun;128:170309. doi: 10.1016/j.peptides.2020.170309. Epub 2020 Apr 5.
CRF system, structural conservation, has an association with feeding regulation in mammals. However, mammals and fish have different physiological mechanisms, the potential role of CRF system for feeding regulation in teleost fish are most unknown. To better explore possible feeding mechanisms of CRF system in Acipenser dabryanus, the gene expression patterns of CRF system have been investigated after different energy status. CRF and two receptors have been studied in Acipenser dabryanus in previous study, thus, four components of CRF system (UI, UCN2, UCN3 and CRF-BP) have been studied in this study. Results showed post-prandial increased UCNs mRNA expressions, and 10 days fasting decreased UCNs mRNA expressions, and the mRNA abundance of CRF-BP has no significant differences. Above, this study confirmed the CRF system has potential role for feeding regulation in Acipenser dabryanus.
CRF 系统，结构保守，与哺乳动物的摄食调节有关。然而，哺乳动物和鱼类具有不同的生理机制，CRF 系统在硬骨鱼类摄食调节中的潜在作用尚不清楚。为了更好地探索 CRF 系统在达氏鲟摄食调节中的可能机制，本研究在不同能量状态下研究了 CRF 系统的基因表达模式。在之前的研究中，已经研究了达氏鲟中的 CRF 和两种受体，因此，本研究研究了 CRF 系统的四个组成部分（UI、UCN2、UCN3 和 CRF-BP）。结果表明，摄食后 UCNs 的 mRNA 表达增加，10 天禁食后 UCNs 的 mRNA 表达减少，而 CRF-BP 的 mRNA 丰度没有显著差异。综上所述，本研究证实了 CRF 系统在达氏鲟摄食调节中具有潜在作用。
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