Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, No. 1068 Xueyuan Avenue, Shenzhen 518055, Guangdong, People's Republic of China; University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Beijing 100049, People's Republic of China.
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, No. 1068 Xueyuan Avenue, Shenzhen 518055, Guangdong, People's Republic of China.
Magn Reson Imaging. 2020 Jul;70:22-28. doi: 10.1016/j.mri.2020.04.001. Epub 2020 Apr 4.
The aim of this work is to implement real-time 3D MR thermometry for high intensity focused ultrasound (HIFU) monitoring.
Volumetric MR thermometry was implemented based on a 3D echo-shifted sequence with short TR to improve temperature sensitivity. The 3D acquisition was accelerated in two phase encoding directions with controlled aliasing in volumetric parallel imaging (CAIPIRINHA). Image reconstruction was run in an open source reconstruction platform (Gadgetron).
Phantom experiments showed the proposed volumetric thermometry was comparable to the fiber optical thermometer. In-vivo animal experiments in rabbit thigh showed that the temperature error before and after 4× acceleration was less than 0.65 °C. Finally, real-time 3D thermometry with temporal resolution ~3 s and spatial resolution 2 × 2 × 5 mm (spatial coverage 192 × 192 × 80 mm) was achieved with Gadgetron reconstruction.
Real-time temperature monitoring was achieved in-vivo by using parallel imaging accelerated 3D echo-shifted sequence with Gadgetron reconstruction.
本研究旨在实现高强度聚焦超声（HIFU）监测的实时三维磁共振测温。
基于具有短重复时间（TR）的三维回波移位序列实现容积磁共振测温，以提高温度灵敏度。通过容积并行成像（CAIPIRINHA）中的相位编码方向的双相加速来实现三维采集。图像重建在开源重建平台（Gadgetron）上运行。
在体模实验中，所提出的容积测温与光纤测温相当。在兔大腿的体内动物实验中，在 4 倍加速前后的温度误差小于 0.65°C。最后，使用 Gadgetron 重建实现了具有约 3s 时间分辨率和 2×2×5mm 空间分辨率（空间覆盖 192×192×80mm）的实时三维测温。
通过使用 Gadgetron 重建的并行成像加速三维回波移位序列，实现了体内实时温度监测。
