El Amrousy Doaa, El-Afify Dalia
Pediatric Department, Faculty of Medicine, Tanta University, Egypt.
Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Egypt.
Cytokine. 2020 Jun;130:155084. doi: 10.1016/j.cyto.2020.155084. Epub 2020 Apr 4.
Obesity is significantly associated with inflammatory process and oxidative stress. Alpha lipoic acid (ALA) is a potent antioxidant that has been reported for reducing weight in animals and obese adults in several studies but no data are available in pediatrics. We investigated the possible beneficial role of ALA in obese children.
Eighty obese children and adolescents were randomized into two groups; the treatment group (n = 40) who received 300 mg of ALA twice daily for 3 months and the control group (n = 40) who received placebo for 3 months. Measurements of weight, body mass index (BMI), lipid profile, fasting blood glucose (FBG), malondialdhyde (MDA), tumor necrosis factor alpha (TNF-α), leptin and adiponectin were carried out before and 3 months after the treatment.
ALA treatment group had a significant reduction of the weight, BMI, MDA, TNF-α, and leptin levels but a significant increase of adiponectin level (P < 0.05) compared to the control group. However, it had no effect on FBG or lipid profile (P > 0.05).
ALA may be a promising supplement in the weight reduction in obese children and adolescents.
肥胖与炎症过程和氧化应激显著相关。α硫辛酸（ALA）是一种强效抗氧化剂，多项研究报道其在动物和肥胖成年人中具有减重作用，但儿科领域尚无相关数据。我们研究了ALA对肥胖儿童可能的有益作用。
80名肥胖儿童和青少年被随机分为两组；治疗组（n = 40）每天两次服用300 mg ALA，持续3个月，对照组（n = 40）服用安慰剂3个月。在治疗前及治疗3个月后测量体重、体重指数（BMI）、血脂谱、空腹血糖（FBG）、丙二醛（MDA）、肿瘤坏死因子α（TNF-α）、瘦素和脂联素。
与对照组相比，ALA治疗组的体重、BMI、MDA、TNF-α和瘦素水平显著降低，但脂联素水平显著升高（P < 0.05）。然而，其对FBG或血脂谱无影响（P > 0.05）。
ALA可能是肥胖儿童和青少年减重的一种有前景的补充剂。
