• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

螯合作用与医学中螯合剂金属配合物的研究进展。

Advances on Chelation and Chelator Metal Complexes in Medicine.

机构信息

Department, Postgraduate Research Institute of Science, Technology, Environment and Medicine, 3 Ammochostou Street, Limassol 3021, Cyprus.

出版信息

Int J Mol Sci. 2020 Apr 3;21(7):2499. doi: 10.3390/ijms21072499.

DOI:10.3390/ijms21072499
PMID:32260293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7177276/
Abstract

Metal ions such as iron, copper and zinc are essential for life. Chelators (Chele, greek χειλή-claw of a crab) are organic molecules possessing specific ligands which have high affinity and can bind/carry metal ions and play very important roles in living systems e.g., haemoglobin, transferrin, phytochelators and microbial siderophores [...].

摘要

金属离子如铁、铜和锌对生命是必不可少的。螯合剂(Chele,希腊语χειλή-螃蟹的爪子)是具有特定配体的有机分子,对金属离子具有高亲和力和结合/携带能力,在生命系统中发挥着非常重要的作用,如血红蛋白、转铁蛋白、植物螯合剂和微生物铁载体[... ]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e00/7177276/38d95c8073aa/ijms-21-02499-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e00/7177276/38d95c8073aa/ijms-21-02499-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e00/7177276/38d95c8073aa/ijms-21-02499-g001.jpg

相似文献

1
Advances on Chelation and Chelator Metal Complexes in Medicine.螯合作用与医学中螯合剂金属配合物的研究进展。
Int J Mol Sci. 2020 Apr 3;21(7):2499. doi: 10.3390/ijms21072499.
2
Synthesis, characterization, and cytotoxicity studies of Cu(II), Zn(II), and Fe(III) complexes of N-derivatized 3-hydroxy-4-pyridiones.N-取代 3-羟基-4-吡啶酮的 Cu(II)、Zn(II) 和 Fe(III) 配合物的合成、表征及细胞毒性研究。
J Inorg Biochem. 2014 Mar;132:59-66. doi: 10.1016/j.jinorgbio.2013.12.003. Epub 2013 Dec 22.
3
Mechanistic Insights of Chelator Complexes with Essential Transition Metals: Antioxidant/Pro-Oxidant Activity and Applications in Medicine.具有必需过渡金属的螯合物配合物的作用机制研究:抗氧化/促氧化活性及其在医学中的应用。
Int J Mol Sci. 2022 Jan 23;23(3):1247. doi: 10.3390/ijms23031247.
4
Preparation of Tetradentate Copper Chelators as Potential Anti-Alzheimer Agents.四齿铜螯合剂的制备作为潜在的抗阿尔茨海默病药物。
ChemMedChem. 2018 Apr 6;13(7):684-704. doi: 10.1002/cmdc.201700734. Epub 2018 Feb 23.
5
Interaction of a chelating agent, 5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one, with Al(III), Cu(II) and Zn(II) ions.一种螯合剂,5-羟基-2-(羟甲基)吡啶-4(1H)-酮,与 Al(III)、Cu(II)和 Zn(II)离子的相互作用。
J Inorg Biochem. 2017 Jun;171:18-28. doi: 10.1016/j.jinorgbio.2017.03.001. Epub 2017 Mar 16.
6
Complex formation equilibria of polyamine ligands with copper(II) and zinc(II).多胺配体与铜(II)和锌(II)的配合物形成平衡。
J Inorg Biochem. 2019 May;194:26-33. doi: 10.1016/j.jinorgbio.2019.02.006. Epub 2019 Feb 18.
7
Regulation of copper and iron homeostasis by metal chelators: a possible chemotherapy for Alzheimer's disease.金属螯合剂对铜和铁动态平衡的调节:阿尔茨海默病的一种潜在化疗方法。
Acc Chem Res. 2015 May 19;48(5):1332-9. doi: 10.1021/acs.accounts.5b00119. Epub 2015 May 6.
8
Characterization of new specific copper chelators as potential drugs for the treatment of Alzheimer's disease.新型特异性铜螯合剂作为治疗阿尔茨海默病潜在药物的特性研究
Chemistry. 2014 May 26;20(22):6771-85. doi: 10.1002/chem.201402143. Epub 2014 May 5.
9
Thermodynamics-based rules of thumb to evaluate the interaction of chelators and kinetically-labile metal ions in blood serum and plasma.基于热力学的经验法则来评估金属络合剂与血清和血浆中动力学不稳定金属离子的相互作用。
Dalton Trans. 2023 Feb 21;52(8):2197-2208. doi: 10.1039/d2dt03875g.
10
Metal Chelation Therapy and Parkinson's Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs.金属螯合疗法与帕金森病:相关金属离子与有前途或已确立药物之间形成配合物的热力学的批判性综述。
Biomolecules. 2019 Jul 9;9(7):269. doi: 10.3390/biom9070269.

引用本文的文献

1
Exploring the Ascorbate Requirement of the 2-Oxoglutarate-Dependent Dioxygenases.探索2-酮戊二酸依赖性双加氧酶的抗坏血酸需求
J Med Chem. 2025 Feb 13;68(3):2219-2237. doi: 10.1021/acs.jmedchem.4c02342. Epub 2025 Jan 30.
2
A Practical Toolkit for the Detection, Isolation, Quantification, and Characterization of Siderophores and Metallophores in Microorganisms.用于检测、分离、定量和表征微生物中铁载体和金属载体的实用工具包。
ACS Omega. 2024 Jun 11;9(25):26863-26877. doi: 10.1021/acsomega.4c03042. eCollection 2024 Jun 25.
3
Towards Clinical Development of Scandium Radioisotope Complexes for Use in Nuclear Medicine: Encouraging Prospects with the Chelator 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid (DOTA) and Its Analogues.

本文引用的文献

1
Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy.铁和铜细胞内螯合作为一种抗癌药物策略
Inorganics (Basel). 2018;6(4). doi: 10.3390/inorganics6040126. Epub 2018 Nov 30.
2
The History of Deferiprone (L1) and the Paradigm of the Complete Treatment of Iron Overload in Thalassaemia.去铁酮(L1)的历史及地中海贫血铁过载完全治疗的范例
Mediterr J Hematol Infect Dis. 2020 Jan 1;12(1):e2020011. doi: 10.4084/MJHID.2020.011. eCollection 2020.
3
Prospects for the introduction of targeted antioxidant drugs for the prevention and treatment of diseases related to free radical pathology.
走向用于核医学的钪放射性同位素配合物的临床开发:用螯合剂 1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)及其类似物带来的可喜前景。
Int J Mol Sci. 2024 May 29;25(11):5954. doi: 10.3390/ijms25115954.
4
The Puzzle of Aspirin and Iron Deficiency: The Vital Missing Link of the Iron-Chelating Metabolites.阿司匹林与缺铁之谜:铁螯合代谢物的关键缺失环节。
Int J Mol Sci. 2024 May 9;25(10):5150. doi: 10.3390/ijms25105150.
5
The Importance and Essentiality of Natural and Synthetic Chelators in Medicine: Increased Prospects for the Effective Treatment of Iron Overload and Iron Deficiency.天然和合成螯合剂在医学中的重要性和必要性:有效治疗铁过载和缺铁症的前景增加。
Int J Mol Sci. 2024 Apr 25;25(9):4654. doi: 10.3390/ijms25094654.
6
Computational Study of Amyloidβ Familial Mutations and Metal Interaction: Impact on Monomers and Aggregates Dynamical Behaviors.淀粉样β蛋白家族突变与金属相互作用的计算研究:对单体和聚集体动力学行为的影响
Inorg Chem. 2024 Mar 11;63(10):4725-4737. doi: 10.1021/acs.inorgchem.3c04555. Epub 2024 Feb 26.
7
Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs.药物选择和剂量、医学中的最佳治疗和风险/效益评估:铁螯合剂药物的范例。
Int J Mol Sci. 2023 Nov 25;24(23):16749. doi: 10.3390/ijms242316749.
8
Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT.基于聚乳酸和金配合物复合物的用于 BNCT 中吸收剂量诊断的纳米复合材料。
Int J Mol Sci. 2023 Nov 18;24(22):16492. doi: 10.3390/ijms242216492.
9
Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications.医学中的铁负荷毒性:从分子和细胞角度到临床意义。
Int J Mol Sci. 2023 Aug 18;24(16):12928. doi: 10.3390/ijms241612928.
10
The Vital Role Played by Deferiprone in the Transition of Thalassaemia from a Fatal to a Chronic Disease and Challenges in Its Repurposing for Use in Non-Iron-Loaded Diseases.去铁酮在将地中海贫血从致命疾病转变为慢性疾病过程中所起的关键作用及其在非铁过载疾病中重新应用面临的挑战
Pharmaceuticals (Basel). 2023 Jul 18;16(7):1016. doi: 10.3390/ph16071016.
引入靶向抗氧化药物预防和治疗自由基病理学相关疾病的前景。
Expert Opin Investig Drugs. 2019 Jul;28(7):593-603. doi: 10.1080/13543784.2019.1631284. Epub 2019 Jun 21.
4
Biocompatibility Studies of Gadolinium Complexes with Iminodiacetic Acid Derivatives.镧系元素配合物的生物相容性研究
Biol Trace Elem Res. 2019 Jun;189(2):426-436. doi: 10.1007/s12011-018-1496-6. Epub 2018 Sep 13.
5
Bilateral Orbital Soft-Tissue Metastases from Renal Neuroendocrine Tumor: Successful Theranostic Application of Ga/Lu-DOTATATE with Improvement of Vision.肾神经内分泌肿瘤的双侧眼眶软组织转移:镓/镥-奥曲肽成功的诊疗应用及视力改善
J Nucl Med Technol. 2019 Jun;47(2):171-172. doi: 10.2967/jnmt.118.217455. Epub 2018 Aug 23.
6
Iron promotes oxidative cell death caused by bisretinoids of retina.铁促进视网膜双视黄醛引起的氧化细胞死亡。
Proc Natl Acad Sci U S A. 2018 May 8;115(19):4963-4968. doi: 10.1073/pnas.1722601115. Epub 2018 Apr 23.
7
A pilot trial of deferiprone in pantothenate kinase-associated neurodegeneration patients.去铁酮治疗泛酸激酶相关神经变性患者的一项试点试验。
Neurol Int. 2018 Feb 15;9(4):7279. doi: 10.4081/ni.2017.7279. eCollection 2017 Dec 11.
8
Metals and Alzheimer's Disease: How Far Have We Come in the Clinic?金属与阿尔茨海默病:我们在临床上走了多远?
J Alzheimers Dis. 2018;62(3):1369-1379. doi: 10.3233/JAD-170662.
9
Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis.去铁酮通过抑制氧化应激诱导的线粒体损伤和细胞凋亡,抑制铁过载诱导的携带组织因子的内皮微粒生成。
Toxicol Appl Pharmacol. 2018 Jan 1;338:148-158. doi: 10.1016/j.taap.2017.11.005. Epub 2017 Nov 10.
10
Iron deposition is associated with differential macrophage infiltration and therapeutic response to iron chelation in prostate cancer.铁沉积与前列腺癌中铁螯合治疗的巨噬细胞浸润和疗效反应有关。
Sci Rep. 2017 Sep 14;7(1):11632. doi: 10.1038/s41598-017-11899-2.