Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan.
Department of Endocrinology and Diabetology, Ayabe City Hospital, Ayabe 623-0011, Japan.
Molecules. 2020 Apr 4;25(7):1667. doi: 10.3390/molecules25071667.
Thrombopoietin (THPO) is a circulatory cytokine that plays an important role in platelet production. The presence of anti-THPO antibody relates to thrombocytopenia and is rarely seen in hematopoietic and autoimmune diseases. To date, there had been no reports that focused on the anti-THPO antibody in patients with type 2 diabetes mellitus (T2DM). To evaluate prevalence of the anti-THPO antibody in patients with T2DM and the relationship between anti-THPO antibody and platelet count, a cross-sectional study was performed on 82 patients with T2DM. The anti-THPO antibody was measured by ELISA using preserved sera and detected in 13 patients. The average platelet count was significantly lower in patients with the anti-THPO antibody than in those without the anti-THPO antibody. Multivariate linear regression analyses showed a significant relationship between the anti-THPO antibody and platelet count, after adjusting for other variables. To our best knowledge, this was the first report on the effect of the anti-THPO antibody on platelet count in patients with T2DM. Further investigation is needed to validate the prevalence and pathological significance of the anti-THPO antibody in patients with T2DM.
血小板生成素（THPO）是一种循环细胞因子，在血小板生成中起重要作用。抗 THPO 抗体的存在与血小板减少症有关，在造血和自身免疫性疾病中很少见。迄今为止，尚无关于 2 型糖尿病（T2DM）患者抗 THPO 抗体的报道。为了评估 T2DM 患者抗 THPO 抗体的患病率以及抗 THPO 抗体与血小板计数之间的关系，对 82 例 T2DM 患者进行了横断面研究。使用保存的血清通过 ELISA 测量抗 THPO 抗体，并在 13 例患者中检测到。与无抗 THPO 抗体的患者相比，抗 THPO 抗体患者的平均血小板计数明显较低。多元线性回归分析表明，在调整其他变量后，抗 THPO 抗体与血小板计数之间存在显著关系。据我们所知，这是第一项关于抗 THPO 抗体对 T2DM 患者血小板计数影响的报告。需要进一步研究来验证 T2DM 患者抗 THPO 抗体的患病率和病理意义。
