Kameta Naohiro, Lee Soo Jin, Masuda Mitsutoshi, Shimizu Toshimi
Nanotube Research Center (NTRC), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.
J Mater Chem B. 2013 Jan 21;1(3):276-283. doi: 10.1039/c2tb00101b. Epub 2012 Nov 1.
A multistep self-assembly process produced one-dimensional nanostructures that consisted of a monolayer membrane functionalized with a ligand that acted as a coordination site for an anticancer Pt complex. Control of the mode of the networks of intermolecular hydrogen bonds within the monolayer membrane of the nanostructures completely determined the morphologies of the one-dimensional nanostructures to be nanotapes having widths of 20-40 nm and nanotubes having widths of 16 nm (8 nm inner diameter and 4 nm membrane thickness). Various spectroscopic measurements and microscopic observations revealed that the ligand in a nanotape was located on the surface, whereas the ligand in a nanotube was selectively located on the inner surface of the nanochannel. We calculated the stability constants of the nanotape and nanotube with an anticancer Pt complex to be 10 and 10, respectively. The nanotape and nanotube were able to not only stably coordinate the anticancer Pt complex in Milli-Q water but also release it in phosphate-buffered saline through a ligand exchange reaction. With respect to sustainable, slow release of the drug, the nanotube, which has a nanochannel to store the drug, was superior to the nanotape.
一个多步自组装过程产生了一维纳米结构，该结构由单层膜组成，该单层膜用一种配体功能化，该配体作为抗癌铂配合物的配位位点。对纳米结构单层膜内分子间氢键网络模式的控制完全决定了一维纳米结构的形态，即宽度为20 - 40 nm的纳米带和宽度为16 nm（内径8 nm，膜厚度4 nm）的纳米管。各种光谱测量和显微镜观察表明，纳米带中的配体位于表面，而纳米管中的配体选择性地位于纳米通道的内表面。我们计算出纳米带和纳米管与抗癌铂配合物的稳定常数分别为10和10。纳米带和纳米管不仅能够在超纯水中稳定地配位抗癌铂配合物，而且能够通过配体交换反应在磷酸盐缓冲盐水中释放它。关于药物的可持续、缓慢释放，具有用于储存药物的纳米通道的纳米管优于纳米带。
