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[暴露于太空飞行因素的大鼠终脑突触的状态]

[Status of the synapses of the end brain of rats exposed to the factors of space flight].

作者信息

Antipov V V, Tikhonchuk V S, Ushakov I B, Fedorov V P

出版信息

Kosm Biol Aviakosm Med. 1988 Jul-Aug;22(4):54-61.

PMID:3226096
Abstract

Using electron microscopy, synapses of different structures of the rat end brain related to cognitive and motor acts (sensorimotor cortex, caudate nucleus) as well as memory and behavior (hippocampus) were examined. Rats were exposed to ionizing radiation, super-high frequency, hypoxia, hyperoxia, vibration and acceleration (applied separately or in combination) which have been traditionally in the focus of space and aviation medicine. Brain interneuronal junctions were found to be very sensitive to the above effects, particularly ionizing radiation and hypoxia. Conversely, synapses were shown to be highly resistant to short-term hyperoxia and electromagnetic radiation. When combined effects were used, responses of interneuronal junctions depended on the irradiation dose and order of application of radiation and other flight factors.

摘要

利用电子显微镜,对大鼠端脑与认知和运动行为(感觉运动皮层、尾状核)以及记忆和行为(海马体)相关的不同结构的突触进行了检查。将大鼠暴露于电离辐射、超高频、缺氧、高氧、振动和加速度(单独或组合应用)下,这些因素传统上一直是空间和航空医学关注的焦点。发现脑内神经元连接对上述影响非常敏感,尤其是电离辐射和缺氧。相反,突触对短期高氧和电磁辐射具有高度抗性。当使用联合效应时,神经元连接的反应取决于辐射剂量以及辐射和其他飞行因素的应用顺序。

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