杂化聚合物囊泡：对囊泡表面进行简便操作以增强细胞相互作用。
Hybrid polymersomes: facile manipulation of vesicular surfaces for enhancing cellular interaction.
作者信息
Su Xingfang, Mohamed Moinuddeen Shaqireen Kwajah, Mori Lucia, Nallani Madhavan
机构信息
Institute of Materials Research and Engineering (A*STAR), 3 Research Link, Singapore 117602.
出版信息
J Mater Chem B. 2013 Nov 14;1(42):5751-5755. doi: 10.1039/c3tb21111h. Epub 2013 Oct 1.
Facile surface modification via the blending of lipids and block-co-polymers to assemble hybrid vesicles was investigated for improving cellular interaction and antigen delivery of poly(ethylene glycol) (PEG)-based polymersomes. Cationic lipids (DOTAP) incorporated into PEG-b-PBD polymersomes increased the binding and uptake of vesicles by antigen-presenting cells, while preserving the stability and biocompatibility of PEG-based polymersomes, resulting in the enhanced cellular delivery of a loaded lipid antigen sulfatide.
研究了通过脂质与嵌段共聚物共混来简便地进行表面修饰以组装混合囊泡，以改善基于聚乙二醇（PEG）的聚合物囊泡的细胞相互作用和抗原递送。掺入PEG-b-PBD聚合物囊泡中的阳离子脂质（DOTAP）增加了抗原呈递细胞对囊泡的结合和摄取，同时保持了基于PEG的聚合物囊泡的稳定性和生物相容性，从而增强了负载脂质抗原硫苷脂的细胞递送。
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