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一类用于生物成像的氨基色烯-苯胺离子共轭远红光至近红外荧光染料的简便合成。

Facile synthesis of a class of aminochromene-aniliniumion conjugated far-red to near-infrared fluorescent dyes for bioimaging.

作者信息

Zheng Kaibo, Lin Weiying, Huang Weimin, Guan Xiaoyu, Cheng Dan, Wang Jian-Yong

机构信息

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, P. R. China.

出版信息

J Mater Chem B. 2015 Feb 7;3(5):871-877. doi: 10.1039/c4tb01592d. Epub 2014 Dec 5.

DOI:10.1039/c4tb01592d
PMID:32262178
Abstract

An innovative class of aminochromene-aniliniumion conjugated far-red to near-infrared dyes, namely ACA, was developed. The design method for ACA dyes is straightforward and the synthesis of the ACA dyes is rapid and convenient. The ACA dyes display absorption and emission in the far-red to near-infrared region, good photostability and chemical stability. The ACA dyes could be used for bio-imaging not only in living cells but also in living animals. The design method described herein may be applicable to other types of long wavelength dyes and the ACA dyes may find interesting applications as sensing and labelling agents in diverse fields.

摘要

开发了一类创新的氨基色烯 - 苯胺离子共轭的远红到近红外染料,即ACA。ACA染料的设计方法简单直接,其合成快速且方便。ACA染料在远红到近红外区域显示吸收和发射,具有良好的光稳定性和化学稳定性。ACA染料不仅可用于活细胞中的生物成像,还可用于活体动物。本文所述的设计方法可能适用于其他类型的长波长染料,并且ACA染料可能在不同领域中作为传感和标记剂找到有趣的应用。

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