Ahmad M, Johnson R F, Fawcett H D, Schreiber M H
Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550.
Magn Reson Imaging. 1988 Sep-Oct;6(5):527-34. doi: 10.1016/0730-725x(88)90127-0.
The role of magnetic resonance imaging in characterizing normal, ischemic and infarcted segments of myocardium was examined in 8 patients with unstable angina, 11 patients with acute myocardial infarction, and 7 patients with stable angina. Eleven normal volunteers were imaged for comparison. Myocardial segments in short axis magnetic resonance images were classified as normal or abnormal on the basis of perfusion changes observed in thallium-201 images in 22 patients and according to the electrocariographic localization of infarction in 4 patients. T2 relaxation time was measured in 57 myocardial segments with abnormal perfusion (24 with reversible and 33 with irreversible perfusion changes) and in 25 normally perfused segments. T2 measurements in normally perfused segments of patients with acute myocardial infarction, unstable angina and stable angina were within normal range derived from T2 measurements in 48 myocardial segments of 11 normal volunteers (42 +/- 10 ms). T2 in abnormal myocardial segments of patients with stable angina also was not significantly different from normal. T2 of abnormal segments in patients with unstable angina (64 +/- 14 in reversibly ischemic and 67 +/- 21 in the irreversibly ischemic segments) was prolonged when compared to normal (p less than 0.0001) and was not significantly different from T2 in abnormal segments of patients with acute myocardial infarction (62 +/- 18 for reversibly and 66 +/- 11 for irreversibly ischemic segments). The data indicate that T2 prolongation is not specific for acute myocardial infarction and may be observed in abnormally perfused segments of patients with unstable angina.(ABSTRACT TRUNCATED AT 250 WORDS)
在8例不稳定型心绞痛患者、11例急性心肌梗死患者和7例稳定型心绞痛患者中，研究了磁共振成像在心肌正常、缺血和梗死节段特征描述中的作用。对11名正常志愿者进行成像以作比较。短轴磁共振图像中的心肌节段，根据22例患者铊-201图像中观察到的灌注变化以及4例患者梗死的心电图定位，分为正常或异常。在57个灌注异常的心肌节段（24个有可逆性灌注变化，33个有不可逆性灌注变化）和25个灌注正常的节段中测量T2弛豫时间。急性心肌梗死、不稳定型心绞痛和稳定型心绞痛患者灌注正常节段的T2测量值在11名正常志愿者48个心肌节段T2测量得出的正常范围内（42±10毫秒）。稳定型心绞痛患者异常心肌节段的T2也与正常情况无显著差异。与正常情况相比，不稳定型心绞痛患者异常节段的T2（可逆性缺血节段为64±14，不可逆性缺血节段为67±21）延长（p<0.0001），且与急性心肌梗死患者异常节段的T2无显著差异（可逆性缺血节段为62±18，不可逆性缺血节段为66±11）。数据表明，T2延长并非急性心肌梗死所特有，在不稳定型心绞痛患者灌注异常的节段中也可观察到。（摘要截于250词）
