Bell Robert V, Rochford Luke A, de Rosales Rafael T M, Stevens Molly, Weaver Jonathan V M, Bon Stefan A F
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
J Mater Chem B. 2015 Jul 21;3(27):5544-5552. doi: 10.1039/c5tb00893j. Epub 2015 Jun 15.
We report on a versatile and time-efficient method to fabricate calcium phosphate (CaP) microcapsules by utilizing oil-in-water emulsion droplets stabilized with synthetic branched copolymer (BCP) as templates. The BCP was designed to provide a suitable architecture and functionality to produce stable emulsion droplets, and to permit the mineralization of CaP at the surface of the oil droplet when incubated in a solution containing calcium and phosphate ions. The CaP shells of the microcapsules were established to be calcium deficient hydroxyapatite with incorporated chlorine and carbonate species. These capsule walls were made fluorescent by decoration with a fluorescein-bisphosphonate conjugate.
我们报道了一种通用且省时的方法，该方法通过利用以合成支化共聚物（BCP）稳定的水包油乳液滴作为模板来制备磷酸钙（CaP）微胶囊。设计BCP是为了提供合适的结构和功能，以产生稳定的乳液滴，并在含有钙离子和磷酸根离子的溶液中孵育时，使CaP在油滴表面矿化。微胶囊的CaP壳层被确定为含有氯和碳酸根物种的缺钙羟基磷灰石。通过用荧光素 - 双膦酸盐共轭物修饰，使这些胶囊壁具有荧光性。
