一种用于检测半胱氨酸（Cys）相对于谷胱甘肽（GSH）/同型半胱氨酸（Hcy）的具有大开启信号的快速响应双光子荧光探针及其在活组织中的应用。
A fast-response two-photon fluorescent probe for the detection of Cys over GSH/Hcy with a large turn-on signal and its application in living tissues.
作者信息
Wang Jian-Yong, Liu Zhan-Rong, Ren Mingguang, Kong Xiuqi, Lin Weiying
机构信息
Institute of Fluorescent Probes for Biological Imaging, School of Materials Science and Engineering, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong 250022, P. R. China.
出版信息
J Mater Chem B. 2017 Jan 7;5(1):134-138. doi: 10.1039/c6tb02610a. Epub 2016 Dec 1.
Cysteine (Cys), a small-molecule aminothiol, plays important roles in various physiological processes in connection with various diseases, such as skin lesions, edema, hair depigmentation and liver damage. We developed a novel two-photon fluorescent probe for sensing Cys in presence of GSH and Hcy in vivo. The two-photon fluorescent probe exhibited favorable properties, including fast response (about 20 min), good selectivity, and low cytotoxicity. Furthermore, it was successfully applied for imaging Cys in living cells and tissues.
半胱氨酸（Cys）是一种小分子氨基硫醇，在与多种疾病相关的各种生理过程中发挥着重要作用，如皮肤损伤、水肿、毛发色素脱失和肝损伤。我们开发了一种新型双光子荧光探针，用于在体内谷胱甘肽（GSH）和同型半胱氨酸（Hcy）存在的情况下检测Cys。该双光子荧光探针具有良好的性能，包括快速响应（约20分钟）、良好的选择性和低细胞毒性。此外，它已成功应用于活细胞和组织中Cys的成像。
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