Kelly T A
Laboure College, Boston, MA 02124.
Med Hypotheses. 1988 Dec;27(4):253-4. doi: 10.1016/0306-9877(88)90001-1.
The lack of secondary infections or the delay in their appearance in immunodeficient individuals (specifically AIDS patients) previously immunized prior to their immune deficit points to an as yet overlooked mechanism in the immune response. It is proposed that on second exposure to the antigen (Ag) there is a unique Ag presentation that alters the Ag in such a way as to induced a state of tolerance.
在免疫缺陷个体（特别是艾滋病患者）中，缺乏继发感染或其出现延迟，这些个体在免疫缺陷之前曾接受过免疫接种，这表明免疫反应中存在一种尚未被重视的机制。有人提出，在再次接触抗原（Ag）时，会有一种独特的抗原呈递，以一种诱导耐受状态的方式改变抗原。
